Results 161 to 170 of about 3,882,403 (320)

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Nuclear safety aspects on the road towards fusion energy

, 2018
Didier Perrault
openalex   +2 more sources

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Thermal energy confinement time of spherical tokamak plasmas in PI3

Nuclear Fusion
The Plasma Injector 3 (PI3) experiment at general fusion has been constructed to demonstrate the ability to form plasma targets suitable for compression in a Magnetized Target Fusion machine.
A. Tancetti, C. Ribeiro, S.J. Howard, S. Coop, C.P. McNally, M. Reynolds, P. Kholodov, F. Braglia, R. Zindler, C. Macdonald, E. Love, P. Carle, X. Feng, A. Rohollahi, K. Leci, D. Plant, C. Dunlea, R. Ivanov, A. Mossman   +18 more
doaj   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Horizontal homing laser for high repetitive inertial fusion

Nuclear Fusion
For a commercial laser inertial fusion energy reactor, a highly repetitive operation in which many fuel pellets must be illuminated by laser spots. One of the most efficient ways to achieve this is to control the laser pointing by following fluctuations ...
Kazuhiro Agatsuma, Kohei Suzuki, Takuya Sugimoto, Kazuki Matsuo, Kenjiro Takahashi, Eiji Sato, Neisei Hayashi, Katsuhiro Ishii, Yoshitaka Mori   +8 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

New England Journal of Medicine, 2018
A. Drilon, T. Laetsch, S. Kummar, S. DuBois, U. Lassen, G. Demetri, M. Nathenson, R. Doebele, A. Farago, A. Pappo, B. Turpin, A. Dowlati, M. Brose, L. Mascarenhas, N. Federman, J. Berlin, W. El-Deiry, C. Baik, J. Deeken, V. Boni, R. Nagasubramanian, Matthew H. Taylor, E. Rudzinski, F. Meric-Bernstam, D. Sohal, P. Ma, L. Raez, J. Hechtman, R. Benayed, M. Ladanyi, Brian B. Tuch, K. Ebata, S. Cruickshank, N. Ku, M. Cox, D. Hawkins, D. Hong, D. Hyman   +37 more
semanticscholar   +1 more source