Results 101 to 110 of about 928,726 (300)

blanket with beaded strip

See notes2.49 mBlue wool blanket with beaded blanket strip down center, two sides bound in red braid. Blanket is made by two pieces sewn together. Blanket strip is 54.0 long, with chalk white background with 5 designs spaced at intervals in green, blue ...
Omaha
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Development of Fusion Reactor Blanket System.

Journal of Plasma and Fusion Research, 1999
In a fusion reactor, the blanket performs the important functions of tritium breeding, heat production, and shielding. System integration must be considered in the blanket’s development and design. This report stresses the importance of system integration and describes recent developments in the materials of the blanket system as well as relevant ...
openaire   +2 more sources

Vacation request for Sophia Good Blanket (Drunkard)

, 1919
Vacation request for Sophia Good Blanket (Drunkard) from her ...
Good Blanket, Irving (Drunkard)
core  

Studies on D-3^He Fusion in LHD [PDF]

, 1996
In LHD ( Large Helical Device ) studies on realization of D-D fusion burning has been carried out, where tritium burning is out of this plan. We propose experiments on D-^3He fusion in this plan. This fueled fusion has the reaction cross-section as large
YAMAZAKI, Kozo, FUJIWARA, Masami, IIYOSHI, Atsuo, SUDO, Shigeru, MURAKAMI, Sadayoshi, KANNO, Ryutaro, TOMITA, Yukihiro, OHYABU, Nobuyoshi, SASAO, Mamiko, OKAMOTO, Masao, KANEKO, Osamu, TAKEIRI, Yasuhiko, MUTOH, Takashi   +12 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Systematic Framework for Risk Assessment of Fusion Blanket: Addressing Manufacturing Defects, Accident Scenarios, and Radioactive Release

Science and Technology of Nuclear Installations
The breeder blanket, as a critical component in fusion reactors, undertakes three essential functions: tritium breeding, neutron shielding, and thermal energy conversion.
Ruonan Zhang, Qigang Wu, Yinfeng Zhu, Jiazhu Li   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source