Results 81 to 90 of about 928,726 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Medical image fusion: A survey of the state of the art [PDF]

, 2014
Medical image fusion is the process of registering and combining multiple images from single or multiple imaging modalities to improve the imaging quality and reduce randomness and redundancy in order to increase the clinical applicability of medical ...
James, Alex Pappachen, Alex Pappachen, James, Dasarathy, Belur V.   +2 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Thermo-mechanics of pebble beds in fusion blankets

, 2008
Thermo-Mechanik von Schüttbetten in Fusionsreaktorblankets Heliumgekühlte Schüttbetten (HCPB: Helium Cooled Pebble Beds) werden in der Ummantelung von Fusionsreaktoren, dem sogenannten Blanket, zur Tritiumerzeugung und als Neutronenmultiplikator verwendet und unterliegen somit harten Einsatzbedingungen.
openaire   +5 more sources

Multivariable optimization of fusion reactor blankets [PDF]

, 1984
The optimization problem consists of four key elements: a figure of merit for the reactor, a technique for estimating the neutronic performance of the blanket as a function of the design variables, constraints on the design variables and neutronic performance, and a method for optimizing the figure of merit subject to the constraints. The first reactor
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Performance of Insulating Materials for Future Fusion Blankets [PDF]

, 1983
In all fusion reactors using the deuterium-tritium fuel cycle, a large fraction (~80%) of the fusion energy will be released as ~14 MeV neutrons. These neutrons must be slowed down in a relatively thick blanket surrounding the plasma and their kinetic energy converted to high temperature heat.
Horn, F. L., Fillo, J. A., Powell, J. R.
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Neutronics analysis of spin-polarized fuel in spherical tokamaks

Nuclear Fusion
The effect of spin-polarized deuterium–tritium fuel on the blanket, magnets, and surrounding structures is analyzed for a spherical tokamak fusion power plant.
Jin Whan Bae, Katarzyna Borowiec, Vittorio Badalassi, Jason Parisi, Ahmed Diallo, Jon Menard, Andrei Khodak, Thomas Brown   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source