Results 51 to 60 of about 3,005 (266)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Research on the optimization method of tritium release efficiency in a water cooled blanket for CFETR

AIP Advances
The Chinese Fusion Engineering Test Reactor (CFETR) is a tokamak device located between ITER and DEMO, with the primary goal of generating useable fusion energy through D–T reactions.
Jie Li, Xianbing Xiang, Xiaoyi Zeng, Haiyan Yang, Jie Zhang   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Conceptual design of solid-type Pb x Li y eutectic alloy breeding blanket for CFETR

Nuclear Fusion, 2023
As a key component of the Chinese Fusion Engineering and Test Reactor (CFETR), the blanket is responsible for tritium breeding, neutron shielding and energy conversion.
K. Jiang, Q. Wu, L. Chen, S. Liu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The effect of Li2TiO3 pebbles on the mechanical properties of ARAA under breeding blanket conditions

Nuclear Materials and Energy
The breeding blanket serves as a critical element for achieving a self-sustaining tritium cycle and generating sufficient energy in fusion reactors.
Yunsong Jung, Youngah Park, Duck Young Ku, Yi-Hyun Park, Hyoseong Gwon   +4 more
doaj   +1 more source

Conceptual design of DEMO blanket materials test modules for A-FNS

Nuclear Materials and Energy, 2020
A conceptual design of Advanced Fusion Neutron Source, A-FNS, has been conducted to achieve early realization of fusion-like neutron irradiation test for fusion reactor materials in Japan.
Saerom Kwon, Satoshi Sato, Masayuki Ohta, Makoto Nakamura, Makoto Oyaidzu, Kentaro Ochiai, Atsushi Kasugai   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Research on Heat Transfer Performance of Different Coolants for the First Wall of the Test Blanket Module of Nuclear Fusion Reactor

南方能源建设
[Introduction] As a clean and efficient energy source, nuclear fusion promises to achieve global sustainable development in the future. For the first wall of Chinese helium-cooled solid breeder test blanket module, the temperature fields of helium, argon
Haolei ZHANG, Tao ZHOU, Chunhui XUE, Peng LIU   +3 more
doaj   +1 more source