Results 11 to 20 of about 2,428,275 (198)

BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility [PDF]

BMC Cancer, 2006
Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Puccetti Elena, Beissert Tim, Güller Saskia, Zheng Xiaomin, Ruthardt Martin   +4 more
doaj   +3 more sources

p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]

Haematologica, 2012
Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian, Anna Metodieva, Yousef Najajreh, Oliver G. Ottmann, Jamal Mahajna, Martin Ruthardt   +5 more
doaj   +2 more sources

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

Blood, 2001
Abstract The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA-associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CML cells transfected with HLA-A*0301, and on primary CML cells from HLA-A3–positive ...
Clark, Richard E, Dodi, I. Anthony, Hill, Seran C, Lill, Jennie L, Aubert, Geraldine, Macintyre, Andrew R, Rojas, José Manuel, Bourdon, Audrey, Bonner, Philip LR, Wang, Lihui, Christmas, Stephen E, Travers, Paul J, Creaser, Colin S, Rees, Robert C, Madrigal, Alejandro   +14 more
openaire   +5 more sources

Peptides spanning the junctional region of both the abl/bcr and the bcr/abl fusion proteins bind common HLA class I molecules [PDF]

Leukemia, 2000
The Philadelphia (Ph) chromosome, resulting from the t(9;22) translocation, is characteristic of chronic myeloid leukemia (CML). As a result of this translocation, two novel chimeric genes are generated and the bcr/abl and abl/bcr fusion proteins expressed.
Berke, Z., Andersen, M.H., Pedersen, M., Fugger, L., Zeuthen, J.and, Haurum, J.S.   +5 more
openaire   +4 more sources

Differential <i>in vivo</i> tyrosine kinase inhibitor sensitivities of pediatric ABL-class Ph-like B-acute lymphoblastic leukemia. [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 9, September 2026.
Sharma R, Dardis JK, Mai HA, Arenas Merizalde C, van de Ven C, Bárcenas López DA, Bhatnagar S, Attarbaschi A, Boer JM, den Boer ML, Tasian SK.   +10 more
europepmc   +2 more sources

Determinants of Abl kinase stability and drug binding thermodynamics: Role of regulatory domains and phosphorylation. [PDF]

Protein Sci
Abstract Activity dysregulation of Abl kinase is the primary cause for chronic myeloid leukemia (CML). Despite extensive characterization, the thermodynamic basis of Abl stability and inhibitor recognition remains incompletely understood. To characterize the cooperative folding organization of Abl and the communication between its structural units, we ...
Juárez-Barragán A, Escobar-Cázares JA, Medina-Gómez MA, Tobías-Juárez I, Luviano A, García-Hernández E.   +5 more
europepmc   +2 more sources

Spontaneous Soft Tissue Haematomas-A Rare Presentation of Chronic Myeloid Leukemia (CML) [PDF]

Journal of Clinical and Diagnostic Research, 2015
Spontaneous soft tissue haematomas are rarely found in haematological malignancies. Chronic myeloid leukemia (CML) is a myeloproliferative disorder which rarely present with thrombo-haemorrhagic phenomenon.
Manoj Lakhotia, Hans Raj Pahadiya, Gopal Raj Prajapati, Akanksha Choudhary, Ronak Gandhi   +4 more
doaj   +1 more source

Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis [PDF]

Biomarker Research, 2014
Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph'). Most patients with CML express e13a2 or e14a2 mRNAs that result from a rearrangement of the major breakpoint cluster regions (M-BCR) generating the 210-kDa
Martinez-Serra, Jordi, del Campo Garcia, Raquel, Gutierrez, Antonio, Antich, Jose Luis, Ginard, Magdalena, Duran Pastor, Maria Antonia, Bento, Leyre, Ros, Teresa, Amat, Juan C, Vidal, Carmen, Iglesias, Julio F, Orlinska, Izabela, Besalduch Vidal, Juan   +12 more
openaire   +3 more sources

Fusion gene bcr-abl: From etiopathogenesis to the management of chronic myeloid leukemia

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2017
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm. CML is relative frequent disorder. Most of CML patients have Philadelphia chromosome (Ph),which is derived from a reciprocal translocation between chromosome 9 and 22, t(9;22)(q34;ql1 ...
Tri Agusti Sholikah
doaj   +1 more source

Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. [PDF]

PLoS ONE, 2012
Chromosomal translocations in tumors frequently produce fusion genes coding for chimeric proteins with a key role in oncogenesis. Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of ...
Álvaro Cuesta-Domínguez, Mara Ortega, Cristina Ormazábal, Matilde Santos-Roncero, Marta Galán-Díez, Juan Luis Steegmann, Ángela Figuera, Eva Arranz, José Luis Vizmanos, Juan A Bueren, Paula Río, Elena Fernández-Ruiz   +11 more
doaj   +1 more source