Results 221 to 230 of about 1,010,581 (327)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

High-Speed Atomic Force Microscopy Reveals Disordered Region-Mediated Structural Plasticity of Anaplastic Lymphoma Kinase Fusion Proteins Induced by Inhibitors. [PDF]

ACS Nano
Han X, Kodera N, Yilmaz N, Sakai K, Arai S, Li B, Imamura R, Voon DC, Fukuda K, Nanjo S, Flechsig H, Mano H, Matsumoto K, Yano S.   +13 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB. [PDF]

Antibodies (Basel)
Claus C, Ferrara-Koller C, Sam J, Lang S, Albrecht R, Buser RB, Bommer E, Sala G, Nicolini VG, Colombetti S, Bacac M, Umaña P, Klein C.   +12 more
europepmc   +1 more source

P0824 INTESTINAL FATTY ACID BINDING PROTEIN AND RISK OF ACUTE PANCREATITIS AFTER POSTERIOR SPINAL FUSION SURGERY [PDF]

, 2004
Zhaoping He, Pravin V. Jadhav, Dalal Tonb, T. Nadal, Frank E. Miller, Suken A. Shah, K. Dabney, R. Brenn, Mary C. Theroux, John McCloskey, Dhaval Mehta   +10 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology. [PDF]

Commun Biol
Elbaum-Mendelson L, Yuan W, Seiler JP, Blom N, Chan YC, Baig AH, Brose N, Rumpel S, Ziv NE.   +8 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection. [PDF]

Cells
Zhang J, Wei L, Song L, Lu X, Tan L, Li X, Fu L, Luo Q, Xie X, Zou Y.   +9 more
europepmc   +1 more source

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy

, 2015
Jian Xu, Xiujun Liu, Liang Li, Shenghua Zhang, Yi Li, Ruijuan Gao, Yong‐Su Zhen   +6 more
openalex   +2 more sources