Results 291 to 300 of about 1,010,581 (327)
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Fusion proteins form onco-condensates
Nature Structural & Molecular Biology, 2021A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco ...
Tanja Mittag, Aseem Z. Ansari
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Fusion proteins in biotechnology
Current Opinion in Biotechnology, 1992Gene fusion techniques allow the production of recombinant proteins featuring the combined characteristics of the parental products. Originally, these techniques were used to probe transcriptional and translational activity, to translocate proteins across cell membranes, and to facilitate the recovery of proteins.
M, Uhlén +4 more
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Protein-Mediated Membrane Fusion
Annual Review of Biophysics and Biophysical Chemistry, 1989PERSPECTIVES AND OVERVIEW 187 GEN ERAL CON CEPTS 188 Fusion Versus Fission 188 Endoplasmic and Exoplasmic Fusion Events 189 Tightness of Fusion 190 PHYSICAL FORCES BETWEEN MEMBRAN ES ........ 190 FUSION ASSAyS 191 LlPOSOMES AS TARGET MEMBRANES 192 EXOPLASMIC FUSION 193 Influenza Virus Fusion 193 Acid-Induced Conformational Change in ...
T, Stegmann, R W, Doms, A, Helenius
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DEPLOYMENT OF MEMBRANE FUSION PROTEIN DOMAINS DURING FUSION
Cell Biology International, 2000AbstractIt is clear that both viral and intracellular membrane fusion proteins contain a minimal set of domains which must be deployed at the appropriate time during the fusion process. An account of these domains and their functions is given here for the four best‐described fusion systems: influenza HA, sendai virus F1, HIV gp120/41 and the neuronal ...
J, Bentz, A, Mittal
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An optimized antigen–protein fusion
Nature Biomedical Engineering, 2020The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.
Pedro Romero +2 more
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Diphtheria Toxin Fusion Proteins
1998Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
F M, Foss +4 more
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Cytokine Fusion Protein Treatment
2002Mice suffering from melanoma can be cured by treatment with a recombinant antibody-lymphotoxin-alpha fusion protein. In order to characterize the involvement of T cells in this syngeneic tumor model, the T cell receptor repertoire was analyzed both quantitatively and qualitatively.
David, Schrama +4 more
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Antibody–cytokine fusion proteins
Archives of Biochemistry and Biophysics, 2012Cytokines are key players in stimulating and regulating immune responses in physiological and pathophysiological processes. Various cytokines have been approved for therapy of cancer and other diseases and many more are under development. However, therapeutic efficacy is often hampered by severe side effects and poor pharmacokinetic properties.
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Feline Ubiquitin Fusion Protein Genes
Veterinary Research Communications, 2001Using cDNA from a CRFK cell line as a template, PCR amplification was performed with the Ub1S and poly(dT) primers to isolate feline ubiquitin genes. Sequencing of the 495 bp PCR fragment revealed that the putative amino acids induced by this fragment gave a fusion protein consisting of a ubiquitin polypeptide (76 amino acids) and an extension protein ...
R, Kano +4 more
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Preparation of GST Fusion Proteins
Cold Spring Harbor Protocols, 2007INTRODUCTIONThis protocol describes the preparation of glutathione-S-transferase (GST) fusion proteins, which have had a wide range of applications since their introduction as tools for synthesis of recombinant proteins in bacteria. GST was originally selected as a fusion moiety because of several desirable properties.
Margret B, Einarson +2 more
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