Results 101 to 110 of about 1,021,734 (270)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Acerca de las normas en defensa de la competencia
Revista de la Facultad de Derecho, 2014 Contenido: Concepto de defensa de la competencia. Razones de la existencia de las normas de defensa de la competencia en el Uruguay. Definición de competencia. Derecho positivo vigente. Control previo de fusiones y adquisiciones.
Román Stebrich Chagas
doaj +2 more sources
, 2001 Many functions on context-free languages can be expressed in the form of the least fixed point of a function whose definition mimics the grammar of the given language. This paper presents the basic theory that explains when a function on a context-free language can be defined in this way.
openaire +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Thēmis, 2023 El presente trabajo es un breve mapa sobre los aspectos contractuales involucrados en las transacciones inmobiliarias de M&A (mergers and acquisitions).
Sergio García Long
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Revista Venezolana de Gerencia, 2003 En los últimos años, las instituciones financieras venezolanas han pasado por varias etapas, tratando de adaptarse a los cambios de la economía nacional.
José Muñoz, Karen Requena
doaj
El camp como detonador de des-fusiones dramáticas: liberación y cinismo en la posmodernidad
Anales del Instituto de Investigaciones EstéticasEl presente trabajo tiene por objetivo pensar las expresiones de la sensibilidad camp como detonadoras de des-fusiones dramáticas. La des-fusión dramática, concepto introducido por Jeffrey Alexander, nos ayudará a medir los alcances de una sensibilidad ...
Alexa Rosales Rivera +1 more
doaj +1 more source