Results 101 to 110 of about 38,172 (289)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Fusión hueso grande-trapezoide: caso clínico [PDF]
, 2010 La sinostosis de los huesos del carpo puede ser una anomalía congénita o adquirida que puede presentarse tanto como un cuadro aislado, como parte de un síndrome de malformaciones congénitas, ó, en el seno de enfermedades metabólicas.
Ballesta Moratalla, M. +3 more
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Thēmis, 2023 El presente trabajo es un breve mapa sobre los aspectos contractuales involucrados en las transacciones inmobiliarias de M&A (mergers and acquisitions).
Sergio García Long
doaj
Las ventajas y desventajas de fusionar las empresas del estado colombiano [PDF]
, 2013 Sin lugar a dudas el mayor beneficiado con las fusiones de las empresas del estado colombiano, es este mismo, son validas las figuras de las crisis económicas de las empresas fusionadas, así como la ineficiencia administrativa de las mismas, no obstante ...
Arias, Carlos Ignacio
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
El camp como detonador de des-fusiones dramáticas: liberación y cinismo en la posmodernidad
Anales del Instituto de Investigaciones EstéticasEl presente trabajo tiene por objetivo pensar las expresiones de la sensibilidad camp como detonadoras de des-fusiones dramáticas. La des-fusión dramática, concepto introducido por Jeffrey Alexander, nos ayudará a medir los alcances de una sensibilidad ...
Alexa Rosales Rivera +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Prognostic significance of telomerase reverse transcriptase promoter gen mutations in high grade meningiomas [PDF]
Biomedica, 2022 Cañas A +31 more
europepmc +1 more source