Results 111 to 120 of about 1,021,734 (270)

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Medicinas que no curan: el problema de la inefectividad de los remedios en las concentraciones empresariales

Thēmis, 2012
El presente artículo, el autor realiza un análisis sobre la pertinencia de una Ley de Control de Fusiones en nuestro país, señalando las críticas, el impacto que tendría, los problemas de aplicación y la experiencia internacional sore el tema.
Mario Fernando Drago Alfaro
doaj  

Prognostic significance of telomerase reverse transcriptase promoter gen mutations in high grade meningiomas [PDF]

Biomedica, 2022
Cañas A, Jiménez E, Hakim F, Mejía JA, Ramón JF, Gómez D, Jaramillo-Velásquez D, Bermúdez S, Useche N, Pineda D, Cifuentes H, Becerra A, Muñoz Á, Santoyo N, Ruíz-Patiño A, Sotelo C, Archila P, Rodríguez J, Ávila J, Ordoñez-Reyes C, García-Robledo JE, Ricaurte L, Rojas L, Feo O, Burgos R, Ramírez C, Arrieta O, Zatarain-Barrón L, Vargas C, Carranza H, Otero J, Cardona AF.   +31 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Síndrome de Gorlin: reporte de un caso

Iatreia, 2010
El síndrome de Gorlin o carcinoma basal nevoide se presenta por mutaciones en el gen PTCH localizado en el cromosoma 9q22.3-q31 este gen codifica una proteína supresora de tumores. Se hereda de forma autosómia dominante y tiene expresividad variable.
Sandra Yaneth Ospina Lagos, Heidi Eliana Mateus   +1 more
doaj  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

La Frailty as a predictor index in spine surgery [PDF]

Rev Fac Cien Med Univ Nac Cordoba, 2021
Pereira Duarte M, Lencina O, Camino Willhuber G, Kido G, Julio B, Petracchi M, Solá C, Gruenberg M.   +7 more
europepmc   +1 more source

Fusion promoter or fusion inhibitor?

The Journal of Cell Biology, 2003
![Graphic][1] Cells in fusogenic conditions (right) have less, rather than more, CD9 (green).Mononuclear phagocytes can fuse to form osteoclasts or multinuclear giant cells. The latter are hallmarks of Crohn's disease, granulomas, tumors, and fungal and HIV infections.
openaire   +2 more sources