Results 41 to 50 of about 3,615,745 (273)

Bad news itself or just the messenger? The high mortality of Fusobacterium spp. infections is related to disseminated malignancy and other comorbidities

European Clinical Respiratory Journal, 2016
Background Fusobacterium species are pleomorphic, obligate anaerobic gram-negative bacilli. They are difficult to culture and grow slowly. If antibiotic treatment is initiated prior to blood cultures, the bacteria might evade detection.
K. Johannesen, R. Dessau, O. Heltberg, U. Bødtger   +3 more
semanticscholar   +1 more source

Pharyngeal abscess complicated by Lemierre’s syndrome: Identification of an atypical germ

IDCases, 2021
Introduction: Lemierre’s syndrome is a rare but serious complication of an oral infection mostly related to Fusobacterium necrophorum. This condition combines jugular vein thrombosis and septic emboli to the lungs or other organs.
Solène Barguil, Audrey Sousa Alves, Jacques-Robert Christen, Cécile De Jerphanion, Joris Valero, Tiphaine Gaillard, Ludovic Karkowski   +6 more
doaj   +1 more source

Fusobacterium nucleatum mediates endothelial damage and increased permeability following single species and polymicrobial infection

The Journal of Periodontology, 2022
Background Numerous lines of evidence link periodontal pathobionts and their virulence factors with endothelial damage. Most research has been conducted using single species infections at the exclusion of other periodontal microorganisms that have been ...
Cher Farrugia, G. Stafford, Ashley F. Gains, Antonia R. Cutts, C. Murdoch   +4 more
semanticscholar   +1 more source

Case report of atypical Lemierre's Syndrome associated with Fusobacterium nucleatum infection without internal or external jugular venous thrombophlebitis

Respiratory Medicine Case Reports, 2022
Fusobacterium nucleatum is an anaerobe that is commensal to the human oral cavity. It is usually a component of periodontal plaque that is emerging as a pathogen and quickly attracting attention of the medical and research communities.
Haidang D. Nguyen, P. Whitley-Williams, L. Uppaluri, J. Sangani, Mitchell L. Simon, Aisha Baig   +5 more
semanticscholar   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Lemierre’s syndrome: A re-emerging infection

IDCases, 2020
Lemierre’s syndrome (LS) or suppurative thrombophlebitis of the jugular vein most often arises as a complication of head and neck infections. LS was more common before the antimicrobial era but the incidence decreased during the 1960s with increased use ...
Takaaki Kobayashi, Loreen Herwaldt
doaj   +1 more source

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

International Journal of Molecular Sciences
Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria
L. Ciani, A. Libonati, Maria Dri, S. Pomella, Vincenzo Campanella, Giovanni Barillari   +5 more
semanticscholar   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study.

Clinical colorectal cancer, 2021
BACKGROUND Fusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis.
Yannick Eisele, P. Mallea, B. Gigic, W. Stephens, C. Warby, K. Buhrke, Tengda Lin, J. Boehm, P. Schrotz-King, S. Hardikar, Lyen C. Huang, T. B. Pickron, C. Scaife, R. Viskochil, Torsten Koelsch, A. Peoples, M. Pletneva, M. Bronner, Martin Schneider, A. Ulrich, Eric A. Swanson, A. Toriola, D. Shibata, Christopher I. Li, E. Siegel, J. Figueiredo, K. Janssen, H. Hauner, J. Round, C. Ulrich, A. Holowatyj, J. Ose   +31 more
semanticscholar   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source