Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
The Future of the Accounting Profession in the Context of the Digitalisation of Tax Administration [PDF]
Maria Bursuc
openalex +1 more source
Prediction of Potential Suitable Habitats of <i>Cupressus duclouxiana</i> Under Climate Change Based on Biomod2 Ensemble Models. [PDF]
Biology (Basel)Li J +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Perceptions of the Role of Diet Among People With Constipation: Dietary Contributors and Relievers to Symptoms and Research Priorities. [PDF]
J Hum Nutr DietFarsi DN, Whelan K, Dimidi E.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Editorial: Challenges and future perspectives of transcatheter valve interventions
Frontiers in Cardiovascular MedicineMohammad Sherif +4 more
doaj +1 more source
Oil shale mining and material handling: Considerations for future research and development
, 1988 Robert P. Smith, C.F. Knutson
openalex +1 more source
Health and Family Factors Predicting Suicidal Ideation Among Middle-Aged Korean Adults: An Explainable Machine Learning Approach. [PDF]
Psychiatry InvestigJo HG +7 more
europepmc +1 more source