Results 271 to 280 of about 20,478,757 (338)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

LSWM: A Long-Short History World Model for Bipedal Locomotion via Reinforcement Learning. [PDF]

Biomimetics (Basel)
Xue J, Liang Z, Mou H, Li Q, Zhang J.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Identifying Conservation and Conflict Zones for Tibetan Brown Bears Under Climate Change Through Integrated Habitat and Prey Modeling on the Qinghai-Tibet Plateau. [PDF]

Ecol Evol
Sun Q, Wanghe K, Dai Y.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Is Europa aan het wieberen? : Future force of future weakness?

, 2015
B.G.J. de Graaff
openalex   +1 more source

Mangrove restoration and coastal flood adaptation: A global perspective on the potential for hybrid coastal defenses. [PDF]

Proc Natl Acad Sci U S A
Tiggeloven T, van Zelst V, Mortensen E, van Wesenbeeck BK, Worthington TA, Spalding M, de Moel H, Ward PJ.   +7 more
europepmc   +1 more source

Precedents for the Future [PDF]

, 1971
Gilbert, Frank B.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Advances in Mental Time Travel Research in Adolescent Depression: A Narrative Review. [PDF]

Alpha Psychiatry
Yuan Y, Liu JL, Ran WT, Wang Y, Chen GF.
europepmc   +1 more source