Results 81 to 90 of about 7,215,084 (246)

Portal hyperperfusion after major liver resection and associated sinusoidal damage is a therapeutic target to protect the remnant liver. [PDF]

, 2019
Extended liver resection results in the loss of a large fraction of the hepatic vascular bed and thereby abrupt alterations in the perfusion of the remnant liver.
Candinas, Daniel, Beldi, Guido, Kohler, Andreas, Frey, Sabrina, Moller, Per Werner, Obrist, Dominik, Tinguely, Pascale, Jakob, Stephan M.   +7 more
core   +2 more sources

The impact of elastography with virtual touch quantification of future remnant liver before major hepatectomy

, 2021
Background: Liver elastography with virtual touch quantification (VTQ) measures the velocity of the shear wave generated by a short-duration acoustic force impulse, with values expressed in units of velocity (m/s).
Kamachi, Hirofumi, Sakamoto, Yuzuru, Kakisaka, Tatsuhiko, Shimada, Shingo, Orimo, Tatsuya, Asahi, Yoh, Nishida, Mutsumi, Kamiyama, Toshiya, Taketomi, Akinobu, Nagatsu, Akihisa, Kudo, Yusuke   +10 more
core   +1 more source

Current Modalities for the Assessment of Future Remnant Liver Function

, 2017
While imaging studies such as computed tomography or magnetic resonance imaging allow the volumetric assessment of the liver segments, only indirect information is provided concerning the quality of the liver parenchyma and its actual functional capacity.
Pim B. Olthof, Roelof J. Bennink, Fadi Rassam, Thomas M. van Gulik   +3 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure

, 2016
Hepatic failure is a feared complication that accounts for up to 75% of mortality after extensive liver resection. Despite improved perioperative care, the increasing complexity and extensiveness of surgical interventions, in combination with an ...
van Mierlo, Kim M. C., Damink, Steven W. M. Olde, Damink, Steven W. M. Olde; id_orcid, Olde Damink, Steven W M., Schaap, Frank G., van Mierlo, Kim M C., Dejong, Cornelis H C., Dejong, Cornelis H. C.   +7 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Neoadjuvant chemotherapy does not affect future liver remnant growth and outcomes of associating liver partition and portal vein ligation for staged hepatectomy

, 2017
BACKGROUND: The only potentially curative treatment for patients with colorectal liver metastases is hepatectomy. Associating liver partition and portal vein ligation for staged hepatectomy has emerged as a method of treatment for patients with ...
Clavien, Pierre Alain, Hernandez-Alejandro, Roberto, Valter, Lars, Malagò, Massimo, Vyas, Soumil, Petrowsky, Henrik, Campos, Ricardo Robles, Wanis, Kerollos, Sandström, Per, Brusadin, Roberto, Linecker, Michael, Machado, Marcel Autran, Hasselgren, Kristina, Björnsson, Bergthor   +13 more
core   +1 more source

Preoperative CT and survival data for patients undergoing resection of colorectal liver metastases

Scientific Data
The liver is a common site for the development of metastases in colorectal cancer. Treatment selection for patients with colorectal liver metastases (CRLM) is difficult; although hepatic resection will cure a minority of CRLM patients, recurrence is ...
Amber L. Simpson, Jacob Peoples, John M. Creasy, Gabor Fichtinger, Natalie Gangai, Krishna N. Keshavamurthy, Andras Lasso, Jinru Shia, Michael I. D’Angelica, Richard K. G. Do   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Comparison of techniques for volumetric analysis of the future liver remnant: implications for major hepatic resections [PDF]

, 2015
ObjectiveThe purpose of this work was to compare measured and estimated volumetry prior to liver resection.MethodsData for consecutive patients submitted to major liver resection for colorectal liver metastases at two centres during 2004–2012 were ...
Belblidia, Assia, Vandenbroucke-Menu, Franck, Cieslak, Kasia P., Dagenais, Michel, Lapointe, Réal, Huang, Ruiyao, Wiggers, Jimme K., Martel, Guillaume, van Lienden, Krijn P., Vandenbroucke‐Menu, Franck, van Gulik, Thomas M.   +10 more
core   +1 more source