Results 41 to 50 of about 458,777 (256)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

FORESIGHT AS A SPECIAL CHARACTERISTIC OF COMPLEX SOCIAL SYSTEMS [PDF]

Interdisciplinary Description of Complex Systems, 2004
There is a great difference between ordinary and emergent complex systems [Funtowitz, S.O. and Ravetz, J.R.: Emergent Complex Systems. Futures 26(6), 568-582, 1994]. One of main differences is the foresight ability of emergent systems.
Eva Hideg
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Mediating Role of Demotivation in the Correlation of Motivational Beliefs, Academic Achievement and Academic Burnout [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2017
Introduction: Since academic motivation is one of the most important factors in learners’ academic achievement, the purpose of this study was to investigate the effect of motivational beliefs (future orientation, task value and self-efficacy) on ...
Fatemeh naseri, Hossein kareshki
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PERAN STATUS SOSIAL EKONOMI ORANGTUA DALAM PENYUSUNAN ORIENTASI MASA DEPAN ANAK

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2016
Children are the future generation that their quality must be maintaied. The quality of the next generation can be realized through a quality education as well. The role of parent to bring the next generation qualified is very important.
Ratna Nurmasari, Hari Wahyono, Agung Haryono   +2 more
doaj   +1 more source

Ethical Decision-Making: The Role of Self-Monitoring, Future Orientation, and Social Networks [PDF]

BAR: Brazilian Administration Review, 2017
This study examines the influence of individual factors (self monitoring, temporal orientation) on social networking, and their relationship with unethical decision-making.
Ana Carla Bon, Roger James Volkema, Jorge Ferreira da Silva   +2 more
doaj   +1 more source

Piloting career development: Whole school interventions

African Journal of Career Development, 2021
Background: The article reports on a project that was undertaken as a pilot study for a whole-school approach (WSA) to career education intervention that was integrated into the Grade 10, Life Orientation (LO) curriculum at a public, secondary school in ...
Kamilla Rawatlal
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source