Results 91 to 100 of about 2,752,614 (333)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
SCIENTIFIC ASPECTS OF MODERN APPROACHES TO MACHINE TRANSLATION FOR SIGN LANGUAGE
Scientific Journal of Astana IT UniversityScientific research in the field of automated sign language translation represents a crucial stage in the development of technologies supporting the hearing-impaired and deaf communities.
Dana Nurgazina +2 more
doaj +1 more source
The Contribution of Event-Related Potentials to the Understanding of Sign Language Processing and Production in the Brain: Experimental Evidence and Future Directions [PDF]
, 2022 Doris Hernández +2 more
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Status and prospects of light bino-higgsino dark matter in natural SUSY
, 2017 Given the recent progress in dark matter direction detection experiments, we examine a light bino-higgsino dark matter (DM) scenario ...
Abdughani, Murat, Wu, Lei, Yang, Jin Min
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Casimir effect for curved geometries: PFA validity limits
, 2006 We compute Casimir interaction energies for the sphere-plate and cylinder-plate configuration induced by scalar-field fluctuations with Dirichlet boundary conditions.
H. B. G. Casimir +4 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Dirac-point photocurrents due to photothermoelectric effect in non-uniform graphene devices
, 2019 Q. Ma et al.[1] recently reported a strong photocurrent associated with charge neutrality in graphene devices with non-uniform geometries, which they interpreted as an intrinsic photoresponse enhanced by the momentum non-relaxing nature of electron ...
Fuhrer, Michael S., Medhekar, Nikhil V.
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source