Results 81 to 90 of about 2,752,614 (333)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Proleptic Ethics vs. Stop Sign Ethics. Theology and Future of Genetics

Svensk Teologisk Kvartalskrift, 2013
Proleptic ethics begins by projecting a vision of a preferred future; then it seeks creative opportunities to actualize the vision. Grounded in God’s eschatological promise of transformation and new creation, proleptic ethics projects a vision of a just,
Ted Peters
doaj  

Signs of a bright future

, 2018
Economy
openaire   +2 more sources

Forcing and response in simulated 20th and 21st century surface energy and precipitation trends

, 2009
A simple methodology is applied to a transient integration of the Met Office Hadley Centre Global Environmental Model version1 (UKMO-HadGEM1) fully coupled atmosphere-ocean general circulation model in order to separate forcing from climate response in ...
Adler, Allan, Allan, Allen, Andrews, Andrews, Boer, Boer, Boer, Collins, Forster, Forster, Gregory, Gregory, Hansen, Hansen, Held, Lambert, Lambert, Lambert, Levitus, Meehl, Mitchell, Mitchell, Nakicenovic, National Research Council, Pielke, Previdi, Ramanathan, Randall, Richter, Romanou, Senior, Shine, Soden, Soden, Stott, Timothy Andrews, Wentz, Wild, Williams, Yang, Yokohata, Yu, Zhang   +44 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

FORMS OF HAND IN SIGN LANGUAGE IN BOSNIA AND HERZEGOVINA – PRACTICAL EXAMPLES [PDF]

Human Research in Rehabilitation, 2014
In this work there is shown illustration of 14 newly discovered forms of hand in sign language (SL) in B&H, and one photographic presentation for each of the signs in which that form of the hand is represented.
Esad H. Mahmutović, Husnija Hasanbegović   +1 more
doaj   +2 more sources

Overview of Sign Language Translation Based on Natural Language Processing [PDF]

ITM Web of Conferences
This paper explores the progress, challenges, and future directions in Sign Language Translation (SLT) within the broader field of Sign Language Processing (SLP), which combines Computer Vision (CV) and Natural Language Processing (NLP) to translate sign
Wang Hanmo
doaj   +1 more source

A new Manifestation of Atomic Parity Violation in Cesium: a Chiral Optical Gain induced by linearly polarized 6S-7S Excitation

, 2002
We have detected, by using stimulated emission, an Atomic Parity Violation (APV) in the form of a chiral optical gain of a cesium vapor on the 7S - 6P$_{3/2}$ transition,consecutive to linearly polarized 6S-7S excitation.
A. V. Papoyan, A. Wasan, C. Bouchiat, D. Chauvat, D. Sarkisyan, D. G. Sarkisyan, E. Jahier, J. Guéna, J. Guéna, J. Guéna, M. A. Bouchiat, M. Lintz, M. A. Bouchiat, M. A. Bouchiat, M. A. Bouchiat, M. A. Bouchiat, M. A. Bouchiat, Ph. Jacquier, S. Sanguinetti   +18 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source