Results 91 to 100 of about 2,692,334 (290)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Future Thinking in Korsakoff Syndrome
Alcohol and Alcoholism, 2019 AbstractAimsPrior research has been mainly concerned with the ability of patients with Korsakoff syndrome (KS) to project themselves into the past. Little is known about the patients’ ability to project themselves into the future. We therefore compared past and future thinking in patients with KS.MethodsWe invited patients with KS and control ...
El Haj, Mohamad +2 more
openaire +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Transport futures: Thinking the unthinkable
Transport Policy, 2013 It is becoming increasingly important to think about longer term possibilities and directions that are trend breaking and can help anticipate the unexpected. The future is perhaps becoming less certain, or at least uncertainty is a central feature of future trajectories.
Banister, D, Hickman, R
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Literature review of scenario methods. W.P. 5-W.P. 4 D.3 final (version 1) [PDF]
, 2006 This document is a literature review of scenario methods elaborated in the frame of ADD TRANS project (2005-2009) . Within this project, WP4 is aimed at the assessment of land use change at the farm level and its impacts on the territory and WP5 is aimed
Gibon, Annick (ed.), Simon, C.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Behavioral Sciences, 2018 Episodic future thinking (EFT), or prospectively imagining yourself in the future, has been developed into an intervention tool to reduce delay discounting (DD), or the preference for smaller immediate over larger future rewards, and to make healthier ...
Sara O’Donnell +2 more
doaj +1 more source