Results 101 to 110 of about 2,692,334 (290)

Technology assessment between risk, uncertainty and ignorance [PDF]

open access: yes, 2012
The use of most if not all technologies is accompanied by negative side effects, While we may profit from today’s technologies, it is most often future generations who bear most risks.
Hillerbrand, Rafaela
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Using Simulation and Critical Thinking in Speech-Language Pathology: A University Case Study [PDF]

open access: yes, 2017
Education is changing. Virtual learning is now a common occurrence. Along with this change, more and more virtual learning tools are being used in the educational setting. The American Speech-Language-Hearing Association (ASHA) has recognized this change
Ellis, Carol M, Ph.D
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Tropical Futurisms: Thinking Futures

open access: yeseTropic: electronic journal of studies in the Tropics
Tropical Futurisms situates the reading of futures in the shared yet multiple modalities of this geo-climatic zone, acknowledging the social and political complexities, technological engagements, multispecies vitalities, and cosmological plurality within tropical regions.
Ysabel Muñoz-Martínez   +3 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Future of Thinking

open access: yes, 2010
How traditional learning institutions can become as innovative, flexible, robust, and collaborative as the best social networking sites. Over the past two decades, the way we learn has changed dramatically. We have new sources of information and new ways to exchange and to interact with information.
Cathy N. Davidson   +2 more
openaire   +2 more sources

Investigating our future: how designers can get us all thinking [PDF]

open access: yes
This paper, and the presentation it represents, discusses the importance of bringing users into the design process and some of the techniques that can be employed to achieve that.
Rust, Chris
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Critical Thinking in Business Education: Current Outlook and Future Prospects [PDF]

open access: yes
This study investigates all available literature related to critical thinking in business education in a survey of publications in the field produced from 1990-2019.
Calma, Angelito, Davies, W. Martin
core  

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