Results 71 to 80 of about 8,453,112 (299)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Siliao yanjiu, 2023 The import and export trade of bulk feed raw materials is key point to ensure normal operation of animal husbandry, which is of great significance to sustainable development of animal husbandry.
LONG Xia, WANG Su-juan
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Frontiers in NutritionBackgroundBreast cancer associated with high red meat consumption has become a significant global health issue. This study aims to analyze the global and regional disease burden related to breast cancer attributable to high red meat diets from 1990 to ...
Yujun Tong +7 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Editorial - [FSRJ]Future Studies Research Journal - V7N1
, 2015 Com satisfação apresentamos a nova edição da Future, a primeira de 2015, com oito artigos que envolvem estudos contábeis, marketing e sociais e outros.Os autores Fernando Maciel Ramos, Roberto Carlos Klann analisam a qualidade da informação contábil das ...
Spers, Renata Giovinazzo
core +1 more source
Open Access Myths : Busted! [PDF]
, 2011 Paper presented at the 2 day Seminar, 8-9 June 2011 "The e-Learning environment: future trends and impact on library services", Sanlam Auditorium, Conference Centre, Hatfield Campus, Pretoria, South Africa ...
De Villiers, Pierre J.T.
core +1 more source
The Future of Artificial Intelligence in Interactive Learning: Trends, Challenges, Opportunities
Engineering ProceedingsThis study explores how artificial intelligence (AI) will evolve and impact interactive learning models in the next two decades. Using a PRISMA-based Systematic Literature Review (SLR) approach, the study analyzes articles published in the last five ...
Teguh Hidayat Iskandar Alam +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source