Results 131 to 140 of about 33,696,977 (337)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Reshaping roles and value logics among distributed system operators for future electricity systems
Energy, Sustainability and SocietyBackground This paper seeks to explore the roles of distribution system operators (DSOs) in future energy systems. Measures to combat climate change have led to a transition in the energy sector, where old system fundamentals are becoming obsolete, which
Martin Warneryd, Kersti Karltorp
doaj +1 more source
Living with the Future in Mind: Goals and Indicators for New Jersey's Quality of Life
, 1999 This report is a "report card" on the long-term trends that can enhance or destroy the quality of life in New Jersey, as well as the lives of those that will inherit the Garden State in the future. Eleven goals are offered in this report, as a result of
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discover PlantsSeashore mangosteen (Garcinia hombroniana) is an underutilized coastal fruit species in Malaysia with ecological, ethnobotanical, and pharmacological potential, yet its scientific and commercial value remains insufficiently synthesized.
Aimi Fadzirul Kamarubahrin +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
DIIDThe digital revolution has catalyzed innovation across multiple sectors, yet the construction industry has been comparatively slow to adopt emerging technologies.
Lisa Giusti Gestri
doaj +1 more source
Learning in Visual Regions as Support for the Bias in Future Value-Driven Choice. [PDF]
Cereb Cortex, 2020 Jahfari S, Theeuwes J, Knapen T.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source