Results 101 to 110 of about 9,288,027 (305)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Editorial: Transforming Education for Sustainable Futures – Views from the Global South

Southern African Journal of Environmental Education
This Special Issue on Transforming Education for Sustainable Futures (TESF) – with its emphasis on views from the global South has been in process for many years and has taken a considerable amount of time to develop and complete.
Heila Lotz-Sisitka
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

AI, education and sociodigital futures: beyond the hype, beyond the obvious

Perspectiva
The constant transformations in social, economic and political contexts driven by datafication and Artificial Intelligence (AI) raise questions about the role of contemporary education in promoting the construction of fairer and decolonial sociodigital ...
Priscila Gonsales, Marisela Gutierrez Lopez, Carolina Valladares-Celis   +2 more
doaj   +1 more source

Metaphors in futures research

, 2016
This special issue, as might be expected in a networked world, searching for proof that collaboration can work, is edited by four of us. It began with a conversation in 2014 over bland conference food in Helsinki between Osmo Kuusi, Matti Minkkinen and ...
Aleksandra Izgarjan, Sohail Inayatullah, Osmo Kuusi, Matti Minkkinen, Izgarjan, Aleksandra, Kuusi O., Minkkinen M., Inayatullah S.   +7 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Bridging the Gap Between Imagined and Plausible Futures for Refugees: What Students Wish Their Teachers Knew

AERA Open
There is a gap between the futures that refugee young people imagine will be possible through their education and the plausible futures in exile, where opportunities are truncated by social, economic, and political exclusions.
Vidur Chopra, Sarah Dryden-Peterson, Joumana Talhouk, Carmen Geha   +3 more
doaj   +1 more source

Teasing Paradoxes to Explore Transformative Futures of Peace [PDF]

This paper discusses the outcome of a methodologically innovative foresight exercise. A Futures Clinique was conducted to address paradoxes of peace. For the purpose, a novel method of p'aradox probing' was launched where paradoxes are employed as tools ...
Heinonen, Sirkka, Taylor, Amos, Pättikangas, Paula, Viitamäki, Riku   +3 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Bringing Futures Thinking to Science Education: Upper Secondary Students' Sense of Future and Agency

, 2020
Due to global crises and accelerating societal change, students have difficulties in projecting themselves in the future as active individuals, citizens and professionals.
Hyvättinen, Tuija Irene, Rasa, Tapio, Pekkala, Paula Kaarina, Levrini, Olivia, Laherto, Antti   +4 more
core