Results 181 to 190 of about 90,485 (281)

Progress of metabolomics‐centric multi‐omics research in medicine

open access: yesiMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang   +6 more
wiley   +1 more source

Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function

open access: yesiMetaOmics, EarlyView.
During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Hao Zhang   +11 more
wiley   +1 more source

microeco 2: A comprehensive R package for downstream analysis of microbiome omics data

open access: yesiMeta, EarlyView.
The current version 2.0 of the microeco package represents a substantial update compared to the previously published version. Key enhancements include the addition of new classes, integration of a broader suite of analytical methods, a comprehensive overhaul of the parameter system, improved connectivity between statistical analysis and visualization ...
Chi Liu   +9 more
wiley   +1 more source

Fuzzy Logic Approaches for Causal Inference in Health Care: Systematic Review. [PDF]

open access: yesJMIR AI
Jamett J   +4 more
europepmc   +1 more source

Deciphering nodal burden in thyroid carcinoma: A dedicated survey of age, lymph node ratio, log odds of positive nodes, and preoperative prediction models

open access: yesJournal of Intelligent Medicine, EarlyView.
Abstract Evidence regarding the prognosis of thyroid carcinoma is heterogeneous, ranging from age effects and nodal burden metrics, such as lymph node ratio (LNR) and log odds of positive nodes (LODDS), to preoperative imaging models comprising ultrasound, CEUS, and radiomics.
Mennatallah Sherif   +2 more
wiley   +1 more source

T2‐Weighted T1 Mapping and Automated Segmentation of CSF: Assessment of Solute Gradients in the Healthy Brain

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebrospinal fluid (CSF) serves as a medium for nutrient delivery and waste clearance. The T1 relaxation rate, R1, can be used to measure the concentration of intrinsic solutes and extrinsic contrast agents. Purpose To implement a method for R1 mapping and segmentation of CSF and to use this method to explore how R1 of CSF relates ...
Tryggve Holck Storås   +9 more
wiley   +1 more source

Optimal Selection of the Effective Echo Time (TEeff) for T2‐Weighted Fast‐Spin‐Echo MRI of the Prostate at 3.0 T: Effect on Lesion Conspicuity

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Clinical T2‐weighted (T2W) MRI of prostate cancer (PCa) usually implements a 2D fast‐spin‐echo (FSE) sequence, but understanding the echo‐time‐dependent contrast behavior is not straightforward due to the complicated FSE signal evolution.
Dahan Kim   +10 more
wiley   +1 more source

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