Spatial biology in cancer epigenetics
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
New Order on Type 2 Fuzzy Numbers
Since Lotfi A. Zadeh introduced the concept of fuzzy sets in 1965, many authors have devoted their efforts to the study of these new sets, both from a theoretical and applied point of view. Fuzzy sets were later extended in order to get more adequate and
Pablo Hernández +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
A New Method for Ranking Fuzzy Numbers Using the Circumcenter and its Application in Performance Evaluation of Supply Chain Management [PDF]
Since much of human reasoning is based on imprecise, vague and subjective values, most of the decision-making processing, in reality, requires handling and evaluation of fuzzy numbers.
Shokouh Sargolzaei +2 more
doaj +1 more source
Inclusion of uncertainty with different types of fuzzy numbers into DEMATEL
Nowadays the multi-criteria decision making is very complicated due to uncertainty, vagueness, limited sources, knowledge and time. The Decision-making Trial and Evaluation Laboratory (DEMATEL) method is a widely used multi-criteria decision-making ...
Tjaša Šmidovnik, Petra Grošel
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
A fuzzy multiobjective algorithm for multiproduct batch plant: Application to protein production [PDF]
This paper addresses the problem of the optimal design of batch plants with imprecise demands and proposes an alternative treatment of the imprecision by using fuzzy concepts.
Dietz, Adrian +4 more
core +1 more source
Tauberian theorems for Cesaro summability of sequences of fuzzy numbers [PDF]
In this paper we use the concept of the Cesaro convergence of a sequence of fuzzy numbers defined by Subrahmanyam [Cesaro summability of fuzzy real numbers, Anal, 7 (1999), 159-168] to prove some Tauberian theorems for sequences of fuzzy numbers and ...
Canak, Ibrahim
core +3 more sources
Empowering Adult Learning How AI Fuels Progress Across Disciplines and Professions
ABSTRACT This article examines the evolving role of artificial intelligence (AI) as a transformative cognitive partner across educational and professional fields. It explores how AI shifts attention away from routine technical tasks and toward human‐centered skills such as critical thinking, ethical decision‐making, and professional judgment.
Rachel Wlodarsky
wiley +1 more source

