Results 61 to 70 of about 3,548 (295)
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi +15 more
wiley +1 more source
Clustering of fMRI data: the elusive optimal number of clusters [PDF]
PeerJ, 2018 Model-free methods are widely used for the processing of brain fMRI data collected under natural stimulations, sleep, or rest. Among them is the popular fuzzy c-mean algorithm, commonly combined with cluster validity (CV) indices to identify the ‘true ...
Mohamed L. Seghier
doaj +2 more sources
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source
A numerical distance based on fuzzy partitions
, 2011 National audienceThis work studies a new distance function which takes into account expert knowledge by making use of fuzzy partitions. It considers the symbolic distances between concepts and is equivalent to the Euclidean distance for regular ...
Patrice Loisel +5 more
core +1 more source
Advanced Science, EarlyView.Here, we demonstrate and investigate polarization‐enabled electromechanical responses in cryogenic physical vapor deposition (cryogenic PVD)‐deposited TexSe1‐x thin films, a tellurium‐based compound with a tunable bandgap and enhanced non‐centrosymmetry.
Chia‐Chen Chung +16 more
wiley +1 more source
Improving fuzzy C-means clustering algorithm based on a density-induced distance measure
The Journal of Engineering, 2014 The authors report an improved fuzzy C-means algorithm in comparison with the conventional one by employing a density-induced distance metric based on a novel calculation method of relative density degree.
Chunhong Lu, Shaoqing Xiao, Xiaofeng Gu
doaj +1 more source
Convex decompositions of fuzzy partitions
, 1979 In this paper we investigate some algebraic and geometric properties of fuzzy partition spaces (convex hulls of hard or conventional partition spaces).
J.Douglas Harris +3 more
core +1 more source
Advanced Science, EarlyView.This study presents an anatomical landmark‐guided DRL framework for autonomous wireless capsule endoscopy navigation. Using a lightweight edge‐contour‐depth fusion module, it achieves over 97% coverage across diverse gastric anatomies. To ensure reliability, a two‐stage sim‐to‐real pipeline with an adaptive dynamic programming controller mitigates ...
Haoxuan Wu +16 more
wiley +1 more source
Tools for analysing fuzzy clusters of sequences data [PDF]
Demographic ResearchBACKGROUND: Sequence analysis is a set of tools increasingly used in demography and other social sciences to analyse longitudinal categorical data. Typically, single (e.g., education trajectories) or multiple parallel temporal processes (e.g., work and ...
Raffaella Piccarreta +1 more
doaj +1 more source