Results 101 to 110 of about 16,303 (230)

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Eliminierung FVIII-spezifischer B-Zellen

, 2018
Hämophilie A ist eine X-chromosomal rezessiv vererbte Krankheit, die aufgrund von Mutationen innerhalb des Gens von Gerinnungsfaktor VIII (FVIII) zum funktionellen Defekt oder zum Fehlen des körpereigenen FVIII führt. FVIII zirkuliert als Heterodimer und
Brettschneider, Kerstin
core  

Kinetic and equilibrium constants for binding of WT-BDD-FVIII and BDD-FVIII mutein proteins to VWF and BO2C11.

, 2015
*Kinetic and equilibrium constants were calculated assuming a 1:1 stoichiometry for binding of FVIII-C2 proteins to the immobilized BO2C11 Fab fragment or to VWF.Kinetic and equilibrium constants for binding of WT-BDD-FVIII and BDD-FVIII mutein proteins ...
Komal Puranik (685812), Kathleen P. Pratt (411067), Muhammad Wamiq-Adhami (685809), Arthur R. Thompson (685813), Jason T. Schuman (685808), Jasper C. Lin (685807), Shelley M. Nakaya-Fletcher (685811), Ai-Hong Zhang (168076), Phuong-Cac T. Nguyen (685810), Ruth A. Ettinger (411066)   +9 more
core   +1 more source

Recombinant factorVIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A [PDF]

, 2015
This work was supported by funding from Biogen, including funding for the editorial and writing support in the the development of this ...
Barnes, C, Nolan, B, Pasi, J, Neelakantan, S, Allen, G, Liesner, R, Gambino, G, Kulkarni, R, Cristiano, LM, Young, G, Pierce, GF, Mahlangu, J   +11 more
core   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +2 more sources

Safety of Damoctocog Alfa Pegol in Patients With Severe Haemophilia A Aged 7 to <12 Years of Age: Pooled Data From PROTECT VIII Kids and Alfa‐PROTECT

Haemophilia, EarlyView.
Margareth C. Ozelo, Anthony K. C. Chan, Matteo Luciani, Monika Maas Enriquez, Claudia Tueckmantel, Maria Elisa Mancuso   +5 more
wiley   +1 more source

Is It Time to Raise the Threshold for Critically Low Fibrinogen? Insights From a Retrospective, Consecutive‐Case Cohort Study of Low Fibrinogen due to Various Causes

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Fibrinogen deficiency is an important coagulation abnormality, with diverse causes. Methods A consecutive‐case cohort study of adult and pediatric patients with low Clauss fibrinogen at four acute care hospitals was undertaken to explore findings, causes, and predictors of outcomes, including the optimal fibrinogen critical value ...
Natalie Mathews, Subia Tasneem, Mana Al Dawsari, Keona Pang, Yasmeen Abulkhair, Guillame Paré, Siraj Mithoowani, Catherine P. M. Hayward   +7 more
wiley   +1 more source

FVIII-containing platelets modulate immune responses and attenuate inhibitor development in hemophilia A mice

Haematologica
Background: Development of inhibitory antibodies (inhibitors) against FVIII is a significant complication of protein replacement therapy in hemophilia A (HA).
Yingyu Chen, Feng Xue, Saurabh Kumar, Jocelyn A. Schroeder, Weiqing Jing, Heyu Ni, Qizhen Shi   +6 more
doaj   +1 more source

Normal thromboelastography with a markedly prolonged activated partial thromboplastin time in severe prekallikrein deficiency: Implications for perioperative hemostatic assessment

Transfusion, EarlyView.
Abstract Background Prekallikrein (PK) deficiency is a rare contact factor deficiency that can markedly prolong the activated partial thromboplastin time (aPTT) without a bleeding phenotype. Because viscoelastic hemostatic assays also rely on contact activation, their behavior in severe PK deficiency is relevant to perioperative evaluation of isolated ...
Jeremy W. Jacobs, Anton Matafonov, Patricia G. Baxter, Qiufang Cheng, Garrett S. Booth, Deva Sharma, Benjamin F. Tillman, David Gailani   +7 more
wiley   +1 more source

Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice

Molecular Therapy: Methods & Clinical Development, 2016
Factor VIII (FVIII) is a large glycoprotein that is challenging to express both in vitro and in vivo. Several studies suggest that high levels of FVIII expression can lead to cellular stress.
Amy M Lange, Ekaterina S Altynova, Giang N Nguyen, Denise E Sabatino   +3 more
doaj   +1 more source