Results 121 to 130 of about 16,303 (230)

Obesity‐Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta‐Analysis

Obesity Reviews, Volume 27, Issue 10, October 2026.
Obesity is widely recognized as a pro‐thrombotic condition, yet the specific biomarker profile reflecting coagulation activation remains incompletely defined. Obesity is associated with increased coagulation activation, particularly in children, suggesting an early pro‐thrombotic shift.
Julia Buchold, Hans‐Jonas Meyer, Manuel Florian Struck, Shrey Kohli, Akash Mathew, Gyulten Mangova, Alexey Surov, Matthias Blüher, Berend Isermann, Silke Zimmermann   +9 more
wiley   +1 more source

Cytokine profile and FVIII inhibitors development in haemophilia A

, 2012
Haemophilia A is a hereditary bleeding disorder linked to the X chromosome characterized by a deficiency or defect in the coagulation factor VIII (FVIII).
Assis, Girley Francisco Machado de, Oliveira, Camila Andrade, Carvalho, Beatriz Nogueira de, Gentz, Solange Henschke Lima, Rodrigues, Cibele Velloso, Martins Filho, Olindo Assis, Chaves, Daniel Gonçalves   +6 more
core   +1 more source

Treatment of hemophilic arthropathy by immunomodulatory extracellular vesicle delivered by liposome hybrid nanoparticles

Bioactive Materials
In individuals afflicted with hemophilia, characterized by a deficiency of coagulation factor VIII (FVIII), the occurrence of spontaneous recurrent intra-articular hemorrhage precipitates the emergence of hemophilic arthropathy (HA).
Dong Wang, Wenzhe Chen, Jiali Chen, Du He, Yanli Pan, Pinger Wang, Qinghe Zeng, Mancang Gu, Peijian Tong, Di Chen, Hongting Jin   +10 more
doaj   +1 more source

FVIII production by human lung microvascular endothelial cells

, 2006
While extrahepatic factor VIII (FVIII) synthesis suffices for hemostasis, the extrahepatic production sites are not well defined. We therefore investigated the ability of the human lungs to produce FVIII. Lungs from heart-beating donors who were declined
Lavend'homme, Renaud, Rega, Filip, Jacquemin, Marc, Peerlinck, Kathelijne, Saint-Remy, Jean-Marie, Neyrinck, Arne, Van Raemdonck, Dirk, Kirkpatrick, Charles James, Hermanns, Maria Iris   +8 more
core   +1 more source

Analyzing 6211 unique variants in the upgraded interactive FVIII web database reveals novel insights into hemophilia A

Blood Vessels, Thrombosis & Hemostasis
: Hemophilia A is a rare genetic disease that occurs with mild, moderate, or severe phenotypes and involves dysfunctional or reduced amounts of plasma factor VIII (FVIII). Identifying causal genetic variants in the F8 gene is vital for patient care.
Emily H. T. Print, Anna M. Simmons, Holly J. Spencer, Christos Efthymiou, Victoria A. Harris, Stephen J. Perkins   +5 more
doaj   +1 more source

Expression of human FVIII coagulation factor in plants

, 2017
Hemophilia A is a inherited bleeding disorder caused by deficiency of coagulation factor VIII (FVIII). The FVIII replacement therapy with infusion of plasma-derived or recombinant functional FVIII protein is the current standard treatment for this ...
FALLARINO F, MATINO D, POMPA A, DE MARCHIS F, SCATTINI G, BELLUCCI M   +5 more
core  

Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs

Experimental and Molecular Medicine
Hemophilia A (HA) is caused by mutations in coagulation factor VIII (FVIII). Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting ...
Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim   +12 more
doaj   +1 more source

A chromogenic substrate method for detecting and titrating anti-factor VIII antibodies in the presence of lupus anticoagulant

Haematologica, 2002
BACKGROUND AND OBJECTIVES. The development of neutralizing anti-factor VIII antibodies (a-fVIII) is a major clinical complication. Lupus anticoagulant (LA) might affect detection of a-fVIII, since both inhibitors may act on the same coagulation pathway ...
AN Blanco, A Alcira Peirano, SH Grosso, LC Gennari, R Perez Bianco, MA Lazzari   +5 more
doaj  

Therapeutic strategies against FVIII immune response in hemophilia A : by modifying FVIII structure, by inhibiting B cells signalisation

, 2017
L’administration de Facteur VIII thérapeutique (FVIII) chez les patients hémophiles A entraine l’apparition d’anticorps anti-FVIII appelés « inhibiteurs » chez 30% des hémophiles A sévères. Ceci constitue alors une impasse thérapeutique. Si de nombreuses
Delignat-Heudier, Sandrine
core  

FVIII [PDF]

, 2019
openaire   +1 more source