Results 31 to 40 of about 12,379,229 (221)

Das Verfahren der anwendungsbegleitenden Datenerhebung für die frühe Nutzenbewertung

Monitor Versorgungsforschung
Am 16. August 2019 trat das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft. Es wurden Änderungen in § 35a SGB V vorgenommen, die es dem Gemeinsamen Bundesausschuss (G-BA) ermöglichen, bei Arzneimitteln zur Behandlung eines ...
Dr. rer. nat. Florian Jantschak, Dr. med. Katharina Wenzel-Seifert, Dr. rer. nat. Tilman Broicher, Dr. med. Maike Schier   +3 more
doaj   +1 more source

Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. [PDF]

PLoS ONE, 2013
Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver by both reducing hepatic BA toxicity and increasing their ...
Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Piotr Milkiewicz, Olivier Barbier   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Tumour necrosis factor-alpha gene polymorphisms in Iranian patients with biliary atresia

African Journal of Paediatric Surgery, 2014
Background: Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts. This study evaluated the relationship between single-nucleotide polymorphisms in the promoter region of tumour necrosis factor-alpha (TNF-α) gene and ...
Nikou Fotouhi, Morteza Bonyadi, Zohreh Jahanafrooz, Nahid Ahmadian, Mahnaz Sadeghi-Shabestari, Saeid Aslanabadi, Robabeh Ghergherehchi, Milad Pormosavi, Mandana Rafeey   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

Cell Death Discovery
Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are responsible for the development of AML, drug resistance and relapse.
Ingrid R. S. B. Dias, Rafaela G. A. Costa, Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Lauren V. Cairns, Ken I. Mills, Daniel P. Bezerra   +11 more
doaj   +1 more source

Content of interleukins-4, 6 and nuclear transcription factor NF-κB in children with atopic bronchial asthma depending on Ile50Val polymorphism of IL4RA gene, severity of the disease course and level of its control

Zaporožskij Medicinskij Žurnal, 2019
Many studies on polymorphic variants of cytokines genes indicate that their role in bronchial asthma development in children is still not fully understood. Aim.
V. M. Dudnyk, L. V. Moroz, N. V. Zaichko, O. V. Kutsak   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Radiolabeled Probes from Derivatives of Natural Compounds Used in Nuclear Medicine

Molecules
Natural compounds are important precursors for the synthesis of new drugs. The development of novel molecules that are useful for various diseases is the main goal of researchers, especially for the diagnosis and treatment of many diseases.
Giuseppe Tesse, Anna Tolomeo, Barbara De Filippis, Letizia Giampietro   +3 more
doaj   +1 more source

The effect of benzyladenine and naphthalene acetic acid on rooting and subsequent growth of Portulaca umbraticola Kunth

Folia Horticulturae, 2010
Portulaca umbraticola Kunth stem cuttings were treated with BA or BA and NAA in different concentrations. BA was applied by spraying or by the quick-dip method.
Wróblewska Katarzyna, Bąbelewski Przemysław   +1 more
doaj   +1 more source