Results 61 to 70 of about 9,283,498 (242)

Ocular and Systemic Pharmacokinetics of Baicalein and Baicalin After Intravitreal Injection and Oral Administration in Mice

open access: yesPharmaceutics
Background: Glaucoma requires therapies that extend beyond intraocular pressure (IOP)-lowering strategies, and baicalein (BA) offers dual IOP-lowering and neuroprotective potential. This study evaluated the pharmacokinetics of BA and its major metabolite
Yunshi Zhi   +5 more
doaj   +1 more source

The Boolean algebra and central Galois algebras

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2001
Let B be a Galois algebra with Galois group G, Jg={b∈B∣bx=g(x)b   for all   x∈B} for g∈G, and BJg=Beg for a central idempotent eg. Then a relation is given between the set of elements in the Boolean algebra (Ba,≤) generated by {0,eg∣g∈G} and a set of ...
George Szeto, Lianyong Xue
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Beneficial effects of barium on the growth, physiology and productivity of wheat

open access: yesScientific Reports
Barium, known to be a toxic element to plants, can adversely affect the photosynthesis and growth of plants at high doses but its effects at low doses on the growth and productivity of wheat are unknown.
Lokesh Kumar Choudhary, A. Kumar
doaj   +1 more source

Inconsistent approaches of the G-BA regarding acceptance of primary study endpoints as being relevant to patients - an analysis of three disease areas: oncological, metabolic, and infectious diseases

open access: yesBMC Health Services Research, 2016
Background Previous evaluations of oncological medicines in the German early benefit assessment (EBA) procedure have demonstrated inconsistent acceptance of endpoints by regulatory authorities and the Federal Joint Committee (G-BA).
Thomas Staab   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

A Matter of “Ba”: Knowledge Creation and Dissemination By Library Faculty at Grand Valley State University

open access: yes, 2008
What is “ba”? I am not a Japanese-speaker; I’m not deeply acquainted with Japanese culture. But in reading about ba and “learning organizations” and knowledge creation, it’s been very easy for me to discern seeds of ba at Grand Valley.
Morrow, Debbie
core  

甘蓝型油菜萝卜质不育系恢复材料Ad-6(F4)测交二代恢复株TCF2的快繁及生根

open access: yes四川大学学报. 自然科学版, 1999
油菜萝卜胞质不育系恢复材料Ad-6(F4)测交二代恢复株TCF2,在MS附加5m g/L6-BA+ 0.5m g/L NAA,3m g/L 6-BA+ 0.2m g/L NAA,3m g/L 6-BA+ 0.3m g/L NAA+600m g/L水解乳蛋白以及5m g/L6-BA+ 0.3m g/LNAA+ 5m g/LAgNO3 的不同培养基上诱导丛生芽,结果表明5m g/L6-BA+ 0.3m g/LNAA+ 5m g/LAgNO3 对TCF2 诱导丛生芽有较好的效果.小芽生根培养基为1 ...
秦金红, 李旭峰, 李琳, 吴书惠
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy