Results 81 to 90 of about 276,085 (274)

The complexity of general-valued CSPs seen from the other side

, 2018
The constraint satisfaction problem (CSP) is concerned with homomorphisms between two structures. For CSPs with restricted left-hand side structures, the results of Dalmau, Kolaitis, and Vardi [CP'02], Grohe [FOCS'03/JACM'07], and Atserias, Bulatov, and ...
Carbonnel, Clement, Romero, Miguel, Zivny, Stanislav   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Localization of Two-Component Bose-Einstein Condensates in Optical Lattices

, 2003
We reveal underlying principles of nonlinear localization of a two-component Bose-Einstein condensate loaded into a one-dimensional optical lattice.
Elena A. Ostrovskaya, M. Cristiani, Yu. S. Kivshar, Yuri S. Kivshar   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Scattering of Elastic Waves in a Quasi-one-dimensional Cavity: Theory and Experiment

, 2013
We study the scattering of torsional waves through a quasi-one-dimensional cavity both, from the experimental and theoretical points of view. The experiment consists of an elastic rod with square cross section.
Báez, G., Cobián-Suárez, M., Martínez-Argüello, A. M., Martínez-Mares, M., Méndez-Sánchez, R. A.   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effect of Ba and Mg as promoter on Ru/g-C3N4 catalyst for CO2 methanation

Journal of CO2 Utilization
Catalytic hydrogenation of CO₂ to produce value-added hydrocarbons is a promising strategy for reducing greenhouse gas emissions and producing renewable fuels and chemicals. In this study, Ru- g-C₃N₄ catalysts were modified with barium (Ba) and magnesium
L. Martínez Quintana, T.H. Vuong, Abdallah I.M. Rabee, J. Rabeah, A.B. Dongil   +4 more
doaj   +1 more source

SIFAT-SIFAT INTEGRAL RIEMANN-STIELTJES

Barekeng, 2007
If is limited and []ℜ→baf,:[]ℜ→ba,:α Monotone increase in [, is Riemann-Stieltjes integral able to α on ] ba,[]ba, simply written by[]αRSf∈ if . With JI=()()xdxfIbaα∫= is called Riemann Stieltjes lower integral f to α and ()()xdxfJbaα∫
Francis Y. Rumlawang, Harimanus Batkunde
doaj   +1 more source