Results 101 to 110 of about 859,407 (298)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Building open lab hardware to tackle antimicrobial resistance [PDF]

Microbiological imaging can be lengthy and labour-intensive without expensive lab-automation. Using Open Source hardware and software, Dr Al Edwards’ Biomedical Technology Lab designed a robot to take high-resolution images of experiments capturing ...
Bull, Stephanie, Edwards, Al, Needs, Sarah   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

G - CODE BASED DATA RECEIVING AND CONTROL SYSTEM

International Journal of Research in Engineering and Technology, 2015
Today in engineering field technical research among the students are increased. To design and develop such hardware projects we may need to collect real time data from Data Acquisition System. These Systems are manufactured by very few companies in India. These systems are very expensive for the students.
openaire   +1 more source

HLA-G coding region polymorphism is skewed in autistic spectrum disorders

Brain, Behavior, and Immunity, 2018
Different isoforms of HLA-G protein are endowed with a differential ability to induce allogenic tolerance during pregnancy. As prenatal immune activation is suggested to play a role in the onset of autistic spectrum disorders (ASD), we evaluated HLA G*01:01-*01:06 allelic polymorphism in a cohort of Italian children affected by ASD (N=111) their ...
F. R. Guerini, E. Bolognesi, M. Chiappedi, E. Ripamonti, A. Ghezzo, M. Zanette, S. Sotgiu, M. M. Mensi, A. Carta, M. P. Canevini, M. Zanzottera, C. Agliardi, A. S. Costa, U. Balottin, M. Clerici   +14 more
openaire   +4 more sources

Multiple configuration shell-core structured robotic manipulator with interchangeable mechatronic joints : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Engineering in Mechatronics at Massey University, Turitea Campus, Palmerston North, New Zealand [PDF]

, 2017
With the increase of robotic technology utilised throughout industry, the need for skilled labour in this area has increased also. As a result, education dealing with robotics has grown at both the high-school and tertiary educational level.
Janse van Vuuren, Jacques J P
core  

Hyperplane Neural Codes and the Polar Complex

, 2019
Hyperplane codes are a class of convex codes that arise as the output of a one layer feed-forward neural network. Here we establish several natural properties of stable hyperplane codes in terms of the {\it polar complex} of the code, a simplicial ...
Allen Hatcher, Anders Björner, Carina Curto, Carina Curto, Dmitry Kozlov, G Cybenko, Hans-Jürgen Bandelt, John O’Keefe, Kurt Hornik, Rebecca Garcia, Torkel Hafting   +10 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source