Results 41 to 50 of about 10,218,057 (244)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
MAGNETIC AND TRANSPORT PROPERTIES OF STAINLESS STEELS AT LOW TEMPERATURE
Acta Metallurgica Slovaca, 2017 Magnetic and transport properties of cold rolled SUS304 stainless steels were investigated via measurements of X-ray diffraction, magnetization, thermoelectric power (TEP), thermal conductivity and electrical resistivity from 300 K down to low ...
Katsuhiko Nishimura +4 more
doaj +1 more source
PLoS ONE, 2020 AimThis study explored the effect of a moderate (90 g/d) low-carbohydrate diet (LCD) in type 2 diabetes patients over 18 months.MethodsNinety-two poorly controlled type 2 diabetes patients aged 20-80 years with HbA1c ≥7.5% (58 mmol/mol) in the previous ...
Chin-Ying Chen +10 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2009 Estudou-se o efeito da interação entre grupo genético e nível de lisina sobre características de desempenho de 576 codornas de corte, de ambos os sexos, de dois grupos genéticos (EV1 e EV2), alimentadas com dietas contendo seis níveis de lisina total, 1 ...
G.G. Santos +9 more
doaj +1 more source
The yield values of densimetric fractions from typical chernozems of different land use types
Бюллетень Почвенного института им. В.В. Докучаева, 2020 One of the most justified and applied approaches to isolating pools of soil organic matter is fractionation in heavy liquids. The main problem with this approach is rather large losses in the separation of fractions at the stage of washing fractions from
Yu. R. Farkhodov +6 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source