Results 61 to 70 of about 10,218,057 (244)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Investigation of the effect of boric acid concentration on neutron reflection coefficient

Nuclear Engineering and Technology
In this study, the neutron reflection coefficient from boric acid solutions was measured at ten concentrations from 1.6 g/L to 16 g/L and thicknesses from 1 cm to 15 cm.
Farnaz Karimi, Farhad Zolfagharpour, Sara Azimkhani   +2 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: The experience of the Tuscan Reference Centre

Journal of Experimental & Clinical Cancer Research, 2008
Background The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma.
Bechi Paolo, Mascitelli Erminia, Gattai Riccardo, Matteini Maria, Pace Marcello   +4 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

MuRe 1.6 Cocreación en Red

, 2017
Mural​ ​CoSo​ ​(Colectivo​ ​y​ ​Sonoro) Duración 10 min. aprox. ; Identidad​ ​Plasmada Duración 10 min. Aprox. ; “Lo​ ​Patrimoniable”​ ​en​ ​los​ territorios​ ​materiales​ ​y​ ​virtuales​ ​de​ ​la​ ​red​ ​MuRe Duración 10 min. Aprox.
Laura​ ​Andrada, Paloma González Helguera​ ​Megan​ ​Dos​ ​Santos,​ ​Agustín​ ​Estol,​ ​Iván​ ​Ibáñez, Denise​ ​Johanson,​ ​Claudia​ ​Márquez ; ​ ​Luciano​ ​López,​ ​Patricia​ ​Garrido,​ ​Florencia​ ​Piriz,​ ​Araceli​ ​Nicolini, Narela​ ​Galván,​ ​Mayra​ ​Rodríguez,​ ​Virginia​ ​Alvarez ; Liliana​ ​Fracasso
core  

Beyond the norm: high protein adherence impacts muscular force and size adaptations

Journal of the International Society of Sports Nutrition
Background 1.6–2.2 g/kg/day of protein is commonly recommended for skeletal muscle development and strength. However, this range is broad and may obscure critical dose–response effects, with emerging evidence suggesting that intakes below 2.0 g/kg/day ...
Gabriella Gilbert, Kyle Travis, Antonella V. Schwarz   +2 more
doaj   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source