Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Senkapis Vilniuje, Čiurlionio g. 3
, 2008 2007 m. lapkričio – 2008 m. vasario mėnesiais pratęsti archeologiniai tyrimai Čiurlionio g. 3 sklype, nugriovus čia stovėjusį medinį pastatą. Archeologiniai tyrimai šiame sklype buvo pradėti dar 2005 m., tada buvo atlikti archeologiniai žvalgomieji tyrimai (tirti 5 šurfai, tyrimus vykdė archeologas a. Vaicekauskas) (ATL 2005 metais, V., 2006, p.
openaire +1 more source
Kapai Vilniuje, M. K. Paco g. 3
, 2022 2021 m. rugpjūčio–spalio mėnesiais Vilniuje, sklype M. K. Paco g. 3 trijų gyvenamųjų namų statybos ir požeminių komunikacijų tiesimo vietose APC atliko detaliuosius tyrimus ir žvalgymus. Sklypo reljefas nelygus, kalvų šlaitai žemėja Š ir P kryptimis, sklypo viduryje esančio keliuko link.
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Synthesis, radiolabelling, and biological assessment of folic acid-conjugated G-3 99mTc-dendrimer as the breast cancer molecular imaging agent. [PDF]
IET Nanobiotechnol, 2020 Zamani S +4 more
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Characterization of a Supersonic Plasma Jet by Means of Optical Emission Spectroscopy
PhotonicsWe discuss an innovative thin film deposition method, Plasma Assisted Supersonic Jet Deposition, which combines the chemistry richness of a reactive cold plasma environment and the assembly control of the film growth allowed by a supersonic jet directed ...
Ruggero Barni +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
One-electron oxidation of ds(5'-GGG-3') and ds(5'-G(8OG)G-3') and the nature of hole distribution: a density functional theory (DFT) study. [PDF]
Phys Chem Chem Phys, 2020 Kumar A +3 more
europepmc +1 more source
Systematic Evaluation of HLA-G 3'Untranslated Region Variants in Locally Advanced, Non-Metastatic Breast Cancer Patients: UTR-1, 2 or UTR-4 are Predictors for Therapy and Disease Outcome. [PDF]
Front Immunol, 2021 Rebmann V +9 more
europepmc +1 more source