Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis [PDF]
Background & AimsProliferation, differentiation, and morphogenesis of the intestinal epithelium are tightly regulated by a number of molecular pathways.
Goto, Akiteru+6 more
core +2 more sources
Fluoride Enhances Alcohol Binding Within a Trigonal‐Prismatic Metal‐Organic Capsule
Steric hindrance from methyl groups orients rectangular ligands “landscape”‐wise, forming a trigonal prismatic capsule with a large cavity. Endohedral functionalization of this capsule via fluoride binding tunes its guest affinity, enhancing the binding of alcohols over ketones and enabling selective perrhenate encapsulation and release, offering an ...
Yuchong Yang+4 more
wiley +2 more sources
Guadalupe pluton–Mariposa Formation age relationships in the southern Sierran Foothills: Onset of Mesozoic subduction in northern California? [PDF]
We report a new 153 ± 2 Ma SIMS U-Pb date for zircons from the hypabyssal Guadalupe pluton which crosscuts and contact metamorphoses upper crustal Mariposa slates in the southern Sierra.
Ernst, W. G.+2 more
core +1 more source
Antagonistic Regulation of Neurite Morphology through Gq/G11 and G12/G13 [PDF]
The induction of neurite retraction and growth cone collapse via G-protein-coupled receptors is involved in developmental as well as regenerative processes. The role of individual G-protein-mediated signaling processes in the regulation of neurite morphology is still incompletely understood. Using primary neurons from brains lacking Galpha(q)/Galpha(11)
Anja U. Bräuer+4 more
openaire +3 more sources
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved+5 more
wiley +2 more sources
Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema [PDF]
Heterotrimeric guanine nucleotide–binding protein (G protein) signaling is a ubiquitous signaling system that links hundreds of G protein–coupled receptors (GPCRs) with four G protein signaling pathways.
Habgood, Anthony+11 more
core +2 more sources
A novel human rotavirus serotype with dual G5-G11 specificity.
Rotavirus serotype G5 isolates were recently recovered from children with diarrhoea in Brazil. Like most human strains, they exhibited long electropherotypes and subgroup II and Wa-like VP4 specificity. We report the successful propagation and the molecular and antigenic characterization of one of these isolates (IAL-28). Cross-neutralization of IAL-28
Rita de Cássia Compagnoli Carmona+4 more
openaire +3 more sources
Spin modulation instabilities and phase separation dynamics in trapped two-component Bose condensates [PDF]
In the study of trapped two-component Bose gases, a widely used dynamical protocol is to start from the ground state of a one-component condensate and then switch half the atoms into another hyperfine state.
Druten, Nicolaas Jan van+2 more
core +2 more sources
Reassortment of Human Rotavirus Gene Segments into G11 Rotavirus Strains
يُعتقد أن فيروسات الروتا G11 من أصل خنزيري. ومع ذلك، تم عزل عدد محدود من فيروسات الروتا G11 مؤخرًا عن البشر بالاشتراك مع P[25] و P[8] و P[6] و P[4]. للتحقيق في العلاقات التطورية لهذه السلالات، قمنا بتحليل الجينوم الكامل لسلالتين بشريتين من G11P [25]، وسلسلتين بشريتين من G11P [8]، و 3 سلالات مرجعية من الخنازير.
Jelle Matthijnssens+10 more
openaire +4 more sources
Killing Spinor Equations from Nonlinear Realisations
Starting from a nonlinear realisation of eleven dimensional supergravity based on the group G11, whose generators appear as low level generators of E11, we present a super extended algebra, which leads to a covariant derivative of spinors identical to ...
André Miemiec+27 more
core +1 more source