Results 91 to 100 of about 41,996 (237)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Phylogenetic tree yielded by G12 dataset.

, 2015
All conserved regions after being aligned were retained. Phylogenetic analyses were based on first and second codon positions of 13 protein-coding genes.
Yue Ma (384284), Xuefang Cheng (148287), Panpan Yu (390907), Jiayong Zhang (440126), Danna Yu (687851), Kun He (178646)   +5 more
core   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Light microscopy images of NCAP droplets with and without different G12 concentrations. Used in Figure 5b.

, 2023
Light microscopy images of NCAP droplets with and without different G12 concentrations. Used in Figure 5b. Note camera artifacts that are not PS droplets.
Einav Tayeb-Fligelman (14805283)
core   +1 more source

Differentiable Randers‐Finsler Eikonal Solvers

Computer Graphics Forum, EarlyView.
Abstract Fast and differentiable solvers for anisotropic and asymmetric distance fields are a key primitive in geometry processing, enabling gradient‐based optimization over metrics, drift fields, and downstream objectives that depend on geodesic distances and geodesics.
Barak Gahtan, Jacob Shpund, Alex M. Bronstein   +2 more
wiley   +1 more source

Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: Emergence of G12 genotype in South India

, 2006
Rotavirus infections by G12 strains in several countries have recently been described. In this study, we report the emergence of G12 strains in south India. Fourteen cases of G12 infection were identified between June and September 2005.
Selvapandian, David, Brown, David W., Kang, Gagandeep, Estes, Mary K., S. Ramani, M. K. Estes, Gray, James J, R. Sarkar, Estes, Mary K, Le Fevre, Andrea M, I. Banerjee, M. Iturriza-Gomara, G. Kang, Jaffar, Shabbar, Le Fevre, Andrea M., B. Primrose Gladstone, J. J. Gray, Gray, James J., Ramani, Sasirekha, A. M. Le Fevre, Banerjee, Indrani, Primrose Gladstone, Beryl, D. Selvapandian, Brown, David W, D. W. Brown, S. Jaffar, Sarkar, Rajiv, Gladstone, Beryl Primrose, Iturriza-Gomara, Miren   +28 more
core   +1 more source

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source

Responsible Innovation Management in Profit‐Driven Firms: A Cross‐Cultural Analysis in Germany, India, and Japan

Journal of Product Innovation Management, EarlyView.
ABSTRACT Responsible innovation (RI) challenges profit‐driven firms to reconcile market pressures with societal and environmental responsibilities. We ask how firms integrate anticipation, reflexivity, inclusion, and responsiveness (ARIR) into responsible innovation management (RIM), and how national context and cultural dimensions shape the degree and
Shashi Matta, Maximilian Bauer, Anna Reith, Tomoko Kawakami, Linda Hamdi‐Kidar, Rajeev Gopalakrishnan   +5 more
wiley   +1 more source

From High-Level Model to Branch-and-Price Solution in G12

, 2008
International audienceThe G12 project is developing a software environment for stating and solving combinatorial problems by mapping a high-level model of the problem to an efficient combination of solving methods.
Puchinger, Jakob, Wallace, Mark, Brand, Sebastian, Stuckey, Peter, J   +3 more
core   +1 more source