Results 181 to 190 of about 127,909 (300)

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

open access: yesBritish Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel   +11 more
wiley   +1 more source

The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans [PDF]

open access: gold, 2007
Fabrício Freitas Fernandes   +5 more
openalex   +1 more source

Performance assessment of a new G12/A1 antibody-based rapid ELISA using commercially available and gluten-spiked food samples [PDF]

open access: green, 2023
Anil K. Verma   +6 more
openalex   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

open access: yesCell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng   +10 more
wiley   +1 more source

Active employees in the future workplace: From job crafting to selfergetic job crafting

open access: yesEuropean Management Review, EarlyView.
Abstract The job crafting theory implies, but does not explicitly present the relationship between the self and the job. To fill the gap, we theorize upon the holistic view of the self, and selfergy, a new concept reflecting the unique manner by which employees craft their jobs. Based on the principles of the self‐determination theory, we have advanced
Louiza Paraskevopoulou   +3 more
wiley   +1 more source

Gαs‐specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins

open access: yesThe FEBS Journal, EarlyView.
Heterotrimeric (αβγ) G proteins are usually inactivated by regulators of G protein signaling (RGS) proteins, but Gαs is an exception. Comparative structural analysis identified unique Gαs structural elements that may interfere with RGS binding. Mutagenesis and biochemical assays showed that three residues in the Gαs GTPase domain are both necessary and
Sabreen Higazy‐Mreih   +4 more
wiley   +1 more source

Moult is associated with higher diversity of food items in the diet of Common Bulbuls (Pycnonotus barbatus) in Cameroon

open access: yesIbis, EarlyView.
Moult is an essential part of birds' annual cycle, and requires sufficient intake of energy and nutrients, but we understand little about how such nutritional requirements are met by wild birds. Using faecal metabarcoding, we analysed the diet of moulting and non‐moulting Common Bulbuls Pycnonotus barbatus, captured in Cameroon.
Crinan Jarrett   +8 more
wiley   +1 more source

Towards Verifiability of Total Value Locked (TVL) in Decentralized Finance [PDF]

open access: yesarXiv
Total Value Locked (TVL) aims to measure the aggregate value of cryptoassets deposited in Decentralized Finance (DeFi) protocols. Although blockchain data is public, the way TVL is computed is not well understood. In practice, its calculation on major TVL aggregators relies on self-reports from community members and lacks standardization, making it ...
arxiv  

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