Results 31 to 40 of about 1,157,795 (274)

Activity of the GR in G2 and Mitosis [PDF]

Molecular Endocrinology, 2002
AbstractTo elucidate the mechanisms mediating the reported transient physiological glucocorticoid resistance in G2/M cell cycle phase, we sought to establish a model system of glucocorticoid-resistant cells in G2. We synchronized various cell lines in G2 to measure dexamethasone (DEX)-induced transactivation of either two endogenous promoters (rat ...
Abel, G., Wochnik, G., Ruegg, J., Rouyer, A., Holsboer, F., Rein, T.   +5 more
openaire   +3 more sources

The Topological G2 String

, 2006
We construct new topological theories related to sigma models whose target space is a seven dimensional manifold of G_2 holonomy. We define a new type of topological twist and identify the BRST operator and the physical states.
Acharya, Acharya, Acharya, Anguelova, Antoniadis, Bershadsky, Blumenhagen, Blumenhagen, de Boer, de Boer, Dijkgraaf, Eguchi, Eguchi, Eguchi, Felder, Figueroa-O'Farrill, Gaberdiel, Gepner, Gerasimov, Grassi, Hitchin, Hitchin, Neitzke, Nekrasov, Nekrasov, Noyvert, Roiban, Roiban, Shatashvili, Sugiyama, Witten,   +30 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Estimating Short-term Default Probabilities Conditional to Economic Conditions: Applications of Regularisation Approach and Economic Adjustment Coefficients

Business Systems Research
Corporate bonds are crucial for corporations as they provide a flexible and often less costly alternative to equity financing. However, rising corporate debt levels, along with rating downgrades and economic uncertainty, can cause corporations to face ...
Mustafa Siti Aisyah, Nor Safwan Mohd, Halim Zairihan Abdul, Zawawi Nur Haiza Muhammad   +3 more
doaj   +1 more source

Euler angles for G2

, 2005
We provide a simple parametrization for the group G2, which is analogous to the Euler parametrization for SU(2). We show how to obtain the general element of the group in a form emphasizing the structure of the fibration of G2 with fiber SO(4) and base H,
Alberto Della Vedova, Antonio Scotti, Bianca L. Cerchiai, Conway J. H., Giovanni Ortenzi, Rothe H. J., Schafer R. D., Sergio L. Cacciatori   +7 more
core   +1 more source

Assessment of W1 and W2 theories for the computation of electron affinities, ionization potentials, heats of formation, and proton affinities [PDF]

, 2001
The performance of two recent {\em ab initio} computational thermochemistry schemes, W1 and W2 theory [J.M.L. Martin and G. de Oliveira, J. Chem. Phys.
Martin, Jan M. L., Parthiban, S.
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hotspots and Trends of Financial Technology (Fintech) Research: A Bibliometric Analysis

ECONOMICS
Fintech has emerged as a force of disruption in the reconfiguration of traditional financial services through technological innovation, while research on this domain remains fragmented.
Abdo Khawla, Qudah Hanan Ahmad, AlQudah Mohammad Zakaria, Almustafa Esmat, Alshaer Basel Yousef   +4 more
doaj   +1 more source

M-theory Compactifications on Manifolds with G2 Structure

, 2004
In this paper we study M-theory compactifications on manifolds of G2 structure. By computing the gravitino mass term in four dimensions we derive the general form for the superpotential which appears in such compactifications and show that beside the ...
Acharya B S, Acharya B S, Acharya B Witten E, Alexander S Becker K Becker M Dasgupta K Knauf A Tatar R, Andrei Micu, Atiyah M, Barrett A B Lukas A, Beasley C, Becker K, Becker K, Becker K Becker M Dasgupta K Tatar R, Becker M, Becker M Dasgupta K, Behrndt K, Behrndt K Cvetic M, Behrndt K Cvetic M, Cardoso G L, Carlos B de Lukas A Morris S, Cascales J F G, Cvetic M Shiu G Uranga A M, Dall'Agata G, Frey A R, Gauntlett J P, Gauntlett J P, Gauntlett J P Martelli D Sparks J Waldram D, Grana M, Gurrieri S, Gurrieri S, House T Lukas A, Joyce D D, Kachru S, Kaste P, Kaste P, Lukas A, Lukas A Saffin P M, Martelli D, Mayer C Mohaupt T, Micu A, Serone M, Thomas House, Wess J, Witten E, Witten E   +42 more
core   +3 more sources

D-brane probes on G2 Orbifolds [PDF]

, 2001
We consider type IIB string theory on a seven dimensional orbifold with holonomy in G2. The motivation is to use D1-branes as probes of the geometry.
Ferretti, G., Salomonson, P., Tsimpis, D.   +2 more
core   +5 more sources