At what cost? The impact of bacteriophage resistance on the growth kinetics and protein synthesis of Escherichia coli. [PDF]
Environ Microbiol RepBacteriophage resistance in Escherichia coli can come at the cost of decreased or even increased bacterial growth rate, yield, and protein synthetic activity as quantified through BONCAT. This study presents different patterns of fitness trade‐offs resulting from various phage‐induced mutational profiles and demonstrates the potential applicability of ...
Landor LAI +5 more
europepmc +2 more sources
Fenugreek Sprouts Around the World: Exploring Therapeutic and Nutritional Benefits. [PDF]
Food Sci NutrThis study delves into the therapeutic and nutritional qualities of fenugreek sprouts sourced from 30 diverse genotypes across different regions. Findings unveil significant genotype‐based variations in therapeutic attributes, including noteworthy antidiabetic and cognitive health benefits among specific genotypes.
Çoban F.
europepmc +2 more sources
Characterization of 2S albumin allergenic proteins for anaphylaxis in common buckwheat. [PDF]
Food Chem (Oxf), 2022 2S albumin (2SA) is responsible for anaphylaxis following consumption of buckwheat in allergic individuals. To reduce allergen incidents, characterization of 2SA polypeptides is prerequisite, thus was analyzed in this study. Of the five 2S albumin genes (
Katsube-Tanaka T, Monshi FI.
europepmc +3 more sources
Effects of novelly synthesized nucleolipides on different tumor cell lines (HT29, HepG2, Panc-1, RenCa) with special respect to glioma cell lines (BT4Ca, GOS3, G28, G112, U251, U87) of human or other species [PDF]
, 2020 Today cancer is the second leading cause of death around the world. The World Health Organization predicts an increase from 9.6 million in 2018 up to 16.4 million cancer deaths in 2040.
Hammerbacher, Katharina
core +3 more sources
Improving Lactose Digestion and Symptoms of Lactose inTolerance with a Novel Galacto-Oligosaccharide (RP-G28): a Randomized, Double-Blind Clinical Trial. [PDF]
Nutrition Journal, 2013 Background Lactose intolerance (LI) is a common medical problem with limited treatment options. The primary symptoms are abdominal pain, diarrhea, bloating, flatulence, and cramping.
Chandler, Justin R +7 more
core +8 more sources
Galacto-Oligosaccharide RP-G28 Improves Multiple Clinical Outcomes in Lactose-Intolerant Patients [PDF]
Nutrients, 2020 Background and Aims: Lactose intolerance (LI) is a global problem affecting more than half of the world’s population. An ultra-purified, high-concentration galacto-oligosaccharide, RP-G28, is being developed as a treatment for patients with LI. The efficacy and safety of RP-G28 in reducing symptoms of lactose intolerance were assessed in a blinded ...
William Chey +5 more
openaire +2 more sources
Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models [PDF]
Cancers, 2020 Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activating mutation. However, this treatment is not curative due to primary and secondary resistance such as T790M mutation in exon 20.
Joana Relat +9 more
openaire +4 more sources
G28 Effective safety netting: an important contribution to avoiding preventable deaths [PDF]
Archives of Disease in Childhood, 2015 Safety netting has conventionally been used during consultations when clinicians are uncertain about the trajectory of an illness to provide patients with guidance about when and where to re-consult (Roland et al 2013). Recent high profile events involving failure to recognise and appropriately safety net children with sepsis highlights this is a ...
Damian Roland +4 more
openaire +2 more sources
EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models [PDF]
Molecules, 2019 Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed in several carcinomas, plays an important role in drug resistance. Furthermore, the enrichment of Breast Cancer Stem Cell (BCSC) features has been found in breast tumors that progressed after chemotherapy. Hence, we used the triple negative breast cancer (TNBC) cell
Ariadna Giró-Perafita +6 more
openaire +6 more sources
On epsilon_K beyond lowest order in the Operator Product Expansion [PDF]
, 2010 We analyse the structure of long distance (LD) contributions to the CP-violating parameter epsilon_K, that generally affect both the absorptive (Gamma_12) and the dispersive (M_12) parts of the K0 -- K0bar mixing amplitude.
Aaltonen +32 more
core +2 more sources