IL‐1β and IL‐6 synergistically drive murine TFH cell differentiation and maintenance in vitro
We define a physiologically relevant in vitro system that demonstrates the combined function of T‐cell receptor signaling, IL‐6 and IL‐1β individually and jointly to promote TFH cell differentiation. These findings identify the essential requirements for generating functional TFH cells and clarify how cytokines shape their differentiation within the ...
Juliana Restrepo Munera, S Rameeza Allie
wiley +1 more source
Subject-Specific Whole-Lung CFPD Coupled with PBPK/PD to Predict Inhaled Bronchodilator Response in Asthmatic and Healthy Subjects. [PDF]
Rajaraman PK +4 more
europepmc +1 more source
Abstract Autosomal polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease. The international guideline developer, Kidney Disease: Improving Global Outcomes (KDIGO), published a 2025 clinical practice guideline reflecting advances in genetic testing and the first disease‐modifying agent, tolvaptan.
Mia E. Abdy +26 more
wiley +1 more source
Pharmacophore-Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases. [PDF]
Kuo CT, Wu YC, Li JM, Ju TC, Tseng TS.
europepmc +1 more source
Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann–Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein [PDF]
Sean Lally +3 more
openalex +1 more source
ABSTRACT Aim To map the scope of nursing work and models of service delivery in Australian primary and secondary schools for children aged 3–18 years. Design Scoping Review. Data Sources A search of CINAHL, Medline, PsycINFO, ERIC, Informit and Google was conducted in August 2024 for peer reviewed, non‐peer reviewed and grey literature giving insight ...
Anita Moyes +5 more
wiley +1 more source
Orientation driven design and mechanical optimization of gyroid TPMS lattice structures. [PDF]
El-Asfoury MS +3 more
europepmc +1 more source
Fundamentals of entrepreneurship (ENT300) : G5 queen steamboat / Nurasmaa' Johari … [et al.] [PDF]
Nurasmaa' Johari +4 more
openalex
Responses of Fruit Flies (Diptera: Tephritidae) to Protein Bait Applied at Different Densities
ABSTRACT The effectiveness of odour‐based lures for insects is related to their active space, the air volume around an odour source in which an insect will detect and move towards it. This principle applies to protein baits laced with toxicants that are used as either sprays or stations to suppress pest fruit fly populations.
Msizi R. Ramaoka +2 more
wiley +1 more source

