Results 141 to 150 of about 1,989,070 (268)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of linseed (Linum usitatissimum L.) germplasm for genetic diversity and G x E interaction

Electronic Journal of Plant Breeding
A comprehensive evaluation of 60 linseed (Linum usitatissimum L.) genotypes was conducted across two contrasting agro-ecological locations—Ludhiana and Gurdaspur—using 10 key agro-morphological traits to assess genetic variability, heritability, genetic ...
Alka, A K. Toor, C. Attri, S. Sharma, N. Sandhu, R. Kapoor   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Environmental concerns and future perspectives related to the legacy of metal(loid) contamination in the vicinity of a dismissed Pb-Zn mining area (Raibl, NE Italy) [PDF]

The occurrence of relevant amounts of potential toxic elements (PTEs) in the environment as a legacy of past extraction and metallurgical activities at decommissioned mining areas represents a worldwide concern, potentially posing a threat to ecosystems ...
Marussi G., Floreani F., Pavoni E., Lenaz D., Covelli S.   +4 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

G×E Interaction Influences Trajectories of Hand Grip Strength. [PDF]

Behav Genet, 2016
Petersen I, Pedersen NL, Rantanen T, Kremen WS, Johnson W, Panizzon MS, Christiansen L, Franz CE, McGue M, Christensen K, Hamdi NR, Krueger RF, Reynolds C.   +12 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Country-wide, multi-location trials of Green Super Rice lines for yield performance and stability analysis using genetic and stability parameters

Scientific Reports
Rice (Oryza sativa L.) is an important member of the family Poaceae and more than half of world population depend for their dietary nutrition on rice. Rice cultivars with higher yield, resilience to stress and wider adaptability are essential to ensure ...
Muhammad Shahzad Ahmed, Abid Majeed, Kotb A. Attia, Rana Arsalan Javaid, Faiza Siddique, Muhammad Shahbaz Farooq, Muhammad Uzair, Seung Hwan Yang, Asmaa M. Abushady   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Multienvironment Testing for Trait Stability and G × E Interaction on N₂ Fixation, Plant Development, and Water-Use Efficiency of 21 Elite Groundnut (Arachis hypogaea L.) Genotypes in the Guinea Savanna. [PDF]

Front Plant Sci, 2019
Oteng-Frimpong R, Dakora FD.
europepmc   +1 more source