Results 21 to 30 of about 3,049 (113)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, Volume 22, Issue 11, 20 February 2026.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, Volume 6, Issue 2, February 2026.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract Fluorescence recovery after photobleaching (FRAP) is a powerful, versatile, and widely accessible tool to monitor molecular dynamics in living cells that can be performed using modern confocal microscopes. Although the basic principles of FRAP are simple, quantitative FRAP analysis requires careful experimental design, data collection, and ...
Charles A. Day, Lewis J. Kraft, Minchul Kang, Anne K. Kenworthy   +3 more
wiley   +1 more source

Lnc‐CHRM4‐2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu, Jie Zang, Lili Zhang, Zhuojian Qu, Haibo Li, Chunjuan Yang, Jiamei Sun, Linlin Gai, Xuecheng Sun, Donghua Xu, Poorani Gurumallesh   +10 more
wiley   +1 more source

Immunotherapy for Leiomyosarcoma: Current Status and Perspectives

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Leiomyosarcoma (LMS), one of the soft‐tissue sarcomas (STSs), has a relatively higher risk of distant metastasis. This has resulted in current first‐line treatments still failing to deliver satisfactory outcomes, and the current treatment of LMS remains controversial and challenging.
Haoyue Qi, Hanxi Zhang, Qin Wang, Xiaolu Wang, Limei Min, Yingling Zhou, Baorui Liu, Rutian Li, Poorani Gurumallesh   +8 more
wiley   +1 more source

Highly Pathogenic Avian Influenza A (H5N1) Caused Mass Death Among Black‐Legged Kittiwakes (Rissa tridactyla) in Norway, 2023

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
In 2023, highly pathogenic avian influenza (HPAI) heavily affected gulls in Europe. In July, a mass mortality event was reported in the black‐legged kittiwake (Rissa tridactyla) breeding colony at Ekkerøy in Northern Norway. The cause was confirmed to be infection with the HPAI H5N1 clade 2.3.4.4b virus, genotype EA‐2022‐BB. We describe the outbreak in
Grim Rømo, Caroline Piercey Åkesson, Tone Kristin Reiertsen, Johanna Hol Fosse, Cathrine Arnason Bøe, Lars Austbø, Johan Åkerstedt, Maryam Saghafian, Morten Helberg, Olav Hungnes, Britt Gjerset, Silje Granstad, Gørill Hogseth, Siri Løtvedt, Anne Døsen, Ragnhild Tønnessen, Linzhu Ren   +16 more
wiley   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Blood biomarkers that correlate with inflammatory demyelination or neurodegeneration are needed for early diagnosis and disease monitoring in multiple sclerosis. This study employed lipidomic analysis to identify serum lipids that are reproducibly altered in relapsing–remitting multiple sclerosis (RRMS) across two independent sample cohorts, finding ...
Lisa Shi, Laura Ghezzi, Georgia Watt, Drishya Mainali, Dana Perantie, Chiara Fenoglio, Collin Tran, Alexander Dupuy, Freda Passam, Monokesh K. Sen, Humphrey Chan, Samuel Kwok, Chenyu Wang, Michael Barnett, Todd Hardy, Laura Piccio, Anthony S. Don   +16 more
wiley   +1 more source

Response to Letter to the Editor: Secondary ganglioside GM2 accumulation in mucopolysaccharidoses

Molecular Genetics and Metabolism Reports, 2022
openaire   +3 more sources