The CB1Cannabinoid Receptor in the Brain
Neurobiology of Disease, 1998 The CB1cannabinoid receptor in brain is a G-protein-coupled receptor that exists as a protein possessing seven transmembrane helices that span the membrane.
Allyn C. Howlett
doaj +1 more source
Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-Arrestin 2 during Homologous Desensitization of the Substance P Receptor [PDF]
, 1999 Larry S. Barak +4 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain. [PDF]
Int J Mol Sci, 2022 Stegen M, Frey UH.
europepmc +1 more source
Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans [PDF]
, 2018 Stefan Lutz +16 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A novel octopamine receptor with preferential expression in Drosophila mushroom bodies [PDF]
, 1998 Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative ...
Han, K-A, Millar, NS
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Fly, 2018 During Drosophila phototransduction, the G protein coupled receptor (GPCR) Rhodopsin (Rh1) transduces photon absorption into electrical signal via G-protein coupled activation of phospholipase C (PLC).
Sudipta Ashe, Shweta Yadav
doaj +1 more source
G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D<sub>2</sub> Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. [PDF]
Biomolecules, 2023 Sánchez-Soto M +12 more
europepmc +1 more source