G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. [PDF]
PLoS ONE, 2017 The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel +12 more
doaj +6 more sources
Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema. [PDF]
Hypertension, 2020 Supplemental Digital Content is available in the text. Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema.
Gambardella J +18 more
europepmc +6 more sources
G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases [PDF]
Frontiers in Immunology, 2022 G protein-coupled receptor kinase 2 (GRK2), an important subtype of GRKs, specifically phosphorylates agonist-activated G protein-coupled receptors (GPCRs).
Nan Li +9 more
doaj +4 more sources
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. [PDF]
Cell Mol Life Sci, 2019 Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an
Penela P +3 more
europepmc +8 more sources
G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases [PDF]
Frontiers in Pharmacology, 2019 G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
Cristina Murga +17 more
doaj +3 more sources
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis [PDF]
EBioMedicine, 2016 In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Laura Nogués +14 more
doaj +3 more sources
Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets. [PDF]
Int J Mol Sci, 2021 Cardiac diseases including heart failure (HF), are the leading cause of morbidity and mortality globally. Among the prominent characteristics of HF is the loss of β-adrenoceptor (AR)-mediated inotropic reserve.
Kayki-Mutlu G, Koch WJ.
europepmc +2 more sources
G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2023 Animals alter their behavior in manners that depend on environmental conditions as well as their developmental and metabolic states. For example, C. elegans is quiescent during larval molts or during conditions of satiety.
Kristen Davis +6 more
doaj +2 more sources
Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2 [PDF]
Frontiers in Pharmacology, 2023 The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction.
Viktor Burström +11 more
doaj +2 more sources
The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor [PDF]
Frontiers in Pharmacology, 2020 G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein ...
Emiliana Echeverría +18 more
doaj +2 more sources