Results 11 to 20 of about 425,489 (192)

G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. [PDF]

PLoS Neglected Tropical Diseases, 2012
Flaviviruses cause a wide range of severe diseases ranging from encephalitis to hemorrhagic fever. Discovery of host factors that regulate the fate of flaviviruses in infected cells could provide insight into the molecular mechanisms of infection and ...
Caroline Le Sommer, Nicholas J Barrows, Shelton S Bradrick, James L Pearson, Mariano A Garcia-Blanco   +4 more
doaj   +4 more sources

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis [PDF]

EBioMedicine, 2016
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor Jr., Petronila Penela   +14 more
doaj   +2 more sources

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2 [PDF]

Journal of Molecular Cell Biology, 2014
This is a pre-copyedited, author-produced pdf of an article accepted for publication in Journal of Molecular Cell Biology following peer review. The version of record Journal of Molecular Cell Biology 6.4 (2014) is available online at: http://dx.doi.org ...
Ana Ruiz-Gómez, Cristina Murga, Federico Mayor, Iria Nieto-Vázquez, Lucia Garcia-Guerra, Mar Ruiz-Gómez, Margarita Lorenzo, Marta Carrasco-Rando, Marta Cruces-Sande, Mercedes Martín, Rocío Vila-Bedmar, Sonia Fernández-Veledo   +11 more
core   +7 more sources

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. [PDF]

J Biol Chem, 2017
G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL.   +5 more
europepmc   +4 more sources

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. [PDF]

J Clin Invest, 2013
Tumor vessel dysfunction is a pivotal event in cancer progression. Using an in vivo neovascularization model, we identified G protein–coupled receptor kinase 2 (GRK2) as a key angiogenesis regulator.
Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW, Hardisson D, Mayor F, Penela P.   +11 more
europepmc   +3 more sources

Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema. [PDF]

Hypertension, 2020
Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled receptors phosphorylated by GRK2 (G protein-coupled receptor kinase 2) with a hitherto ...
Gambardella J, Sorriento D, Bova M, Rusciano M, Loffredo S, Wang X, Petraroli A, Carucci L, Mormile I, Oliveti M, Bruno Morelli M, Fiordelisi A, Spadaro G, Campiglia P, Sala M, Trimarco B, Iaccarino G, Santulli G, Ciccarelli M.   +18 more
europepmc   +5 more sources

The roles of G protein-coupled receptor kinase 2 in renal diseases. [PDF]

J Cell Mol Med
AbstractG protein‐coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signalling network cascades. An emerging study indicates that GRK2 can interact with GPCRs and non‐GPCR substrates in both kinase‐dependent and ‐independent modes. Alterations in the functional levels of GRK2 have been found in a variety of renal diseases, such as ...
Du J, Wu X, Ni L.
europepmc   +3 more sources

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. [PDF]

Cell Mol Life Sci, 2019
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain
Penela P, Ribas C, Sánchez-Madrid F, Mayor F.   +3 more
europepmc   +7 more sources

Peptide substrates for G protein‐coupled receptor kinase 2 [PDF]

FEBS Letters, 2014
G protein‐coupled receptor kinases (GRKs) control the signaling and activation of G protein‐coupled receptors through phosphorylation. In this study, consensus substrate motifs for GRK2 were identified from the sequences of GRK2 protein substrates, and 17 candidate peptides were synthesized to identify peptide substrates with high affinity for GRK2 ...
Asai, Daisuke, Toita, Riki, Murata, Masaharu, Katayama, Yoshiki, Nakashima, Hideki, Kang, Jeong-Hun   +5 more
openaire   +2 more sources

G protein receptor kinase type 2: A novel target in cardiovascular drug development [PDF]

Hospital Pharmacology, 2014
In spite of significant advancement in pharmacotherapy, heart failure remains one of the main causes of death worldwide. The existing treatment of heart failure prolongs life span by slowing down the pathological process but does not induce heart healing.
Vasić Marko S., Japundžić-Žigon Nina M.   +1 more
doaj   +1 more source