Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure. [PDF]
Circ Res, 2016 Rationale Sympathetic nervous system (SNS) hyperactivity is associated with poor prognosis in patients with HF, yet routine assessment of SNS activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase 2 (GRK2) is up-
Rengo G +16 more
europepmc +2 more sources
Circulation Research, 2010 Rationale: Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein–coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R) models. GPCR signaling pathways are regulated by GPCR kinases
Philip Raake, Erhe Gao, Walter Koch
exaly +2 more sources
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin* [PDF]
Journal of Biological Chemistry, 1998 The G protein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase that phosphorylates and desensitizes agonist-occupied G protein-coupled receptors (GPCRs).
J. Pitcher +9 more
semanticscholar +3 more sources
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol [PDF]
Journal of Medicinal Chemistry, 2010 G protein-coupled receptor kinase 2 (GRK2) is a pharmaceutical target for the treatment of cardiovascular diseases such as congestive heart failure, myocardial infarction, and hypertension.
J. Tesmer +4 more
semanticscholar +3 more sources
G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer [PDF]
Molecular Pharmacology, 2017 Malignant features-such as sustained proliferation, refractoriness to growth suppressors, resistance to cell death or aberrant motility, and metastasis-can be triggered by a variety of mutations and signaling adaptations. Signaling nodes can act as cancer-associated factors by cooperating with oncogene-governed pathways or participating in compensatory
Laura Nogués +5 more
semanticscholar +3 more sources
The roles of G protein-coupled receptor kinase 2 in renal diseases. [PDF]
J Cell Mol MedAbstractG protein‐coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signalling network cascades. An emerging study indicates that GRK2 can interact with GPCRs and non‐GPCR substrates in both kinase‐dependent and ‐independent modes. Alterations in the functional levels of GRK2 have been found in a variety of renal diseases, such as ...
Du J, Wu X, Ni L.
europepmc +3 more sources
Mechanisms of adrenocorticotropin-induced activation of erk 1/2 map kinase in the human H295R adrenal cell line [PDF]
, 2008 PhDThe role of ACTH in stimulating or inhibiting growth of adrenal cells has been a subject of some controversy. Reports that ACTH may stimulate Erk/MAP kinase in Y1 cells have suggested a role for cAMP in this process.
Janes, Mandy Elaine
core +4 more sources
Mdm2 is involved in the ubiquitination and degradation of G‐protein‐coupled receptor kinase 2 [PDF]
The EMBO Journal, 2006 G-protein-coupled receptor kinase 2 (GRK2) is a central regulator of G-protein-coupled receptor signaling. We report that Mdm2, an E3-ubiquitin ligase involved in the control of cell growth and apoptosis, plays a key role in GRK2 degradation. Mdm2 and GRK2 association is enhanced by beta(2)-adrenergic receptor stimulation and beta-arrestin.
Alicia Salcedo, F. Mayor, P. Penela
semanticscholar +3 more sources
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2 [PDF]
Molecular and Cellular Biology, 2006 Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli.
A. Meloni +7 more
semanticscholar +3 more sources