Results 21 to 30 of about 425,489 (192)
Frontiers in Molecular Biosciences, 2022 Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors.
Masanori Honsho +2 more
doaj +1 more source
Clathrin Box in G Protein-coupled Receptor Kinase 2 [PDF]
Journal of Biological Chemistry, 2001 beta(1)-Adrenergic receptor (beta(1)AR) shows the resistance to agonist-induced internalization. However, beta(1)AR can internalize as G protein-coupled receptor kinase 2 (GRK2) is fused to its carboxyl terminus. Internalization of the beta(1)AR and GRK2 fusion protein (beta(1)AR/GRK2) is dependent on dynamin but independent of beta-arrestin and ...
T, Shiina +6 more
openaire +2 more sources
Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis. [PDF]
Mol Cell Oncol, 2014 Downregulation of G protein-coupled receptor kinase 2 (GRK2) in endothelial cells has recently been identified as a relevant event in the tumoral angiogenic switch. Based on the effects of altering GRK2 dosage in cell and animal models, this kinase appears to act as a hub in key signaling pathways involved in vascular stabilization and remodeling ...
Rivas V +4 more
europepmc +5 more sources
MAPK-dependent Degradation of G Protein-coupled Receptor Kinase 2 [PDF]
Journal of Biological Chemistry, 2003 G protein-coupled receptor kinase 2 (GRK2) is a key modulator of G protein-coupled receptors (GPCR). Altered expression of GRK2 has been described to occur during pathological conditions characterized by impaired GPCR signaling. We have reported recently that GRK2 is rapidly degraded by the proteasome pathway and that beta-arrestin function and Src ...
Ana, Elorza +3 more
openaire +2 more sources
eLife, 2021 G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser +6 more
doaj +1 more source
Chemical Genetic Engineering of G Protein-coupled Receptor Kinase 2 [PDF]
Journal of Biological Chemistry, 2005 G protein-coupled receptor kinases (GRKs) play a pivotal role in receptor regulation. Efforts to study the acute effects of GRKs in intact cells have been limited by a lack of specific inhibitors. In the present study we have developed an engineered version of GRK2 that is specifically and reversibly inhibited by the substituted nucleotide analog 1 ...
Denise M, Kenski +3 more
openaire +2 more sources
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression
Frontiers in Molecular Biosciences, 2023 Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti ...
Cierra A. Birch +6 more
doaj +1 more source
Degradation of the G Protein-coupled Receptor Kinase 2 by the Proteasome Pathway [PDF]
Journal of Biological Chemistry, 1998 GRK2 is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family and has been shown to play a key role in determining the desensitization and resensitization patterns of a variety of G protein-coupled receptors. In this report, we show that GRK2 is actively degraded by the proteasome proteolytic pathway, unveiling a new mechanism for ...
P, Penela +3 more
openaire +2 more sources
Ecotoxicology and Environmental Safety, 2022 Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei +5 more
doaj +1 more source
Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries [PDF]
, 2010 Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase ...
Ansar, S., Edvinsson, L., Sandhu, Hardip
core +1 more source