Results 31 to 40 of about 37,687,396 (313)

Peptide substrates for G protein‐coupled receptor kinase 2 [PDF]

FEBS Letters, 2014
G protein‐coupled receptor kinases (GRKs) control the signaling and activation of G protein‐coupled receptors through phosphorylation. In this study, consensus substrate motifs for GRK2 were identified from the sequences of GRK2 protein substrates, and 17 candidate peptides were synthesized to identify peptide substrates with high affinity for GRK2 ...
Asai, Daisuke, Toita, Riki, Murata, Masaharu, Katayama, Yoshiki, Nakashima, Hideki, Kang, Jeong-Hun   +5 more
openaire   +2 more sources

G protein receptor kinase type 2: A novel target in cardiovascular drug development [PDF]

Hospital Pharmacology, 2014
In spite of significant advancement in pharmacotherapy, heart failure remains one of the main causes of death worldwide. The existing treatment of heart failure prolongs life span by slowing down the pathological process but does not induce heart healing.
Vasić Marko S., Japundžić-Žigon Nina M.   +1 more
doaj   +1 more source

Clathrin Box in G Protein-coupled Receptor Kinase 2 [PDF]

Journal of Biological Chemistry, 2001
beta(1)-Adrenergic receptor (beta(1)AR) shows the resistance to agonist-induced internalization. However, beta(1)AR can internalize as G protein-coupled receptor kinase 2 (GRK2) is fused to its carboxyl terminus. Internalization of the beta(1)AR and GRK2 fusion protein (beta(1)AR/GRK2) is dependent on dynamin but independent of beta-arrestin and ...
T, Shiina, K, Arai, S, Tanabe, N, Yoshida, T, Haga, T, Nagao, H, Kurose   +6 more
openaire   +2 more sources

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) [PDF]

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +4 more sources

Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity

Frontiers in Molecular Biosciences, 2022
Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors.
Masanori Honsho, Shiro Mawatari, Takehiko Fujino   +2 more
doaj   +1 more source

Genetic association between G protein-coupled receptor kinase 6/β-arrestin 2 and dopamine supersensitivity psychosis in schizophrenia

Neuropsychiatric Disease and Treatment, 2015
Yasunori Oda,1 Nobuhisa Kanahara,2 Hiroshi Kimura,1 Hiroyuki Watanabe,2 Kenji Hashimoto,3 Masaomi Iyo1 1Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan; 2Division of Medical Treatment and Rehabilitation, 3Division of
Oda Y, Kanahara N, Kimura H, Watanabe H, Hashimoto K, Iyo M   +5 more
doaj   +1 more source

Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis. [PDF]

Mol Cell Oncol, 2014
Downregulation of G protein-coupled receptor kinase 2 (GRK2) in endothelial cells has recently been identified as a relevant event in the tumoral angiogenic switch. Based on the effects of altering GRK2 dosage in cell and animal models, this kinase appears to act as a hub in key signaling pathways involved in vascular stabilization and remodeling ...
Rivas V, Nogués L, Reglero C, Mayor F, Penela P.   +4 more
europepmc   +5 more sources

MAPK-dependent Degradation of G Protein-coupled Receptor Kinase 2 [PDF]

Journal of Biological Chemistry, 2003
G protein-coupled receptor kinase 2 (GRK2) is a key modulator of G protein-coupled receptors (GPCR). Altered expression of GRK2 has been described to occur during pathological conditions characterized by impaired GPCR signaling. We have reported recently that GRK2 is rapidly degraded by the proteasome pathway and that beta-arrestin function and Src ...
Ana, Elorza, Petronila, Penela, Susana, Sarnago, Federico, Mayor   +3 more
openaire   +2 more sources

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb, Moritz Bünemann   +6 more
doaj   +1 more source

Chemical Genetic Engineering of G Protein-coupled Receptor Kinase 2 [PDF]

Journal of Biological Chemistry, 2005
G protein-coupled receptor kinases (GRKs) play a pivotal role in receptor regulation. Efforts to study the acute effects of GRKs in intact cells have been limited by a lack of specific inhibitors. In the present study we have developed an engineered version of GRK2 that is specifically and reversibly inhibited by the substituted nucleotide analog 1 ...
Denise M, Kenski, Chao, Zhang, Mark, von Zastrow, Kevan M, Shokat   +3 more
openaire   +2 more sources