Results 1 to 10 of about 4,856 (131)

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction [PDF]

Cells
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes
Gizem Kayki Mutlu, Stephanie M. Kereliuk, Maya Hoteit, J. Kurt Chuprun, Umur Mendes, Yusuf Olgar, Walter J. Koch   +6 more
doaj   +2 more sources

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

Neurobiology of Disease, 2013
G protein-coupled receptor (GPCR) kinase 2 (GRK2) regulates cellular signaling via desensitization of GPCRs and by direct interaction with intracellular signaling molecules. We recently described that ischemic brain injury decreases cerebral GRK2 levels.
Annemieke Kavelaars, Pierre Gressens, Cobi J Heijnen   +2 more
exaly   +3 more sources

miR-181a post-transcriptionally targets GRK2 to limit maladaptive signaling in cardiomyocytes [PDF]

Frontiers in Cardiovascular Medicine
BackgroundPathological upregulation of G protein-coupled receptor kinase 2 (GRK2) is a hallmark of heart failure and contributes to maladaptive signaling, hypertrophic remodeling, and cardiomyocyte death.
Heidi Cho, Heidi Cho, Melissa Lieu, Erhe Gao, Stephanie M. Kereliuk, Samuel Slone, Thiele Osvaldt Rosales, Christina Liu, Maya Hoteit, Eric Barr, J. Kurt Chuprun, Walter J. Koch   +11 more
doaj   +2 more sources

G-Protein-Coupled Receptor Kinase 2 Limits CCL21-Induced T Cell Migration via Phospholipase Cγ1 [PDF]

Receptors
Background/Objectives: G protein-coupled receptors (GPCRs) can promote ligand-biased signaling, yet the mechanisms that promote bias are not well understood.
Anahi Sanchez, Caitlin T. Winebrenner, Natalia Garcia, Brian Kaiser, Lyndsey Kilgore, Cesar I. Cardona, Daniel W. Bassuk, Mary E. Miller, Charles A. Bill, Laura A. Shannon, Brant M. Wagener, Amy Wagler, Manuel Llano, Colin A. Bill, Charlotte M. Vines   +14 more
doaj   +2 more sources

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

EBioMedicine, 2016
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Vanesa Lafarga, Xiao Zhen Zhou, Konstantinos Stamatakis   +2 more
exaly   +3 more sources

GRK2 inhibits Flt-1 macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity.
Yingjie Zhao, Wei Wei, Xuezhi Yang
exaly   +3 more sources

Regulation of G protein-coupled receptor kinase 2 and its role in tumors [PDF]

Journal of Translational Medicine
Background G protein-coupled receptor kinase 2(GRK2) is a pivotal regulator of G protein-coupled receptor (GPCR) signal desensitization. It is increasingly recognized for its involvement in the pathogenesis of various malignancies through non-canonical ...
Chenmin Liu, Liuli Yang, Shiyu Peng, Jiangbo Jing, Lijuan Ma   +4 more
doaj   +2 more sources

Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction [PDF]

Cell Death Discovery
Hypoxia, a condition characterized by a temporary lack of oxygen, causes mitochondrial damage, which in turn leads to endothelial dysfunction. G-protein-coupled receptor kinase 2 (GRK2) plays a key role in vascular homeostasis and remodeling, influencing
Cristina Gatto, Maria Rosaria Rusciano, Daniela Sorriento, Paola Di Pietro, Angela Carmelita Abate, Valeria Visco, Nicola Montone, Pasquale Mone, Daniele Di Napoli, Pierpaolo Chivasso, Vito Domenico Bruno, Vincenza Valerio, Paolo Poggio, Guido Iaccarino, Gaetano Santulli, Carmine Vecchione, Albino Carrizzo, Michele Ciccarelli   +17 more
doaj   +2 more sources

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Acta Pharmaceutica Sinica B, 2021
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei   +12 more
doaj   +1 more source

Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. [PDF]

PLoS ONE, 2013
Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction.
Qian Fan, Mai Chen, Lin Zuo, Xiying Shang, Maggie Z Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J Chuprun, Gerald W Dorn, Walter J Koch, Erhe Gao   +11 more
doaj   +1 more source