Results 1 to 10 of about 9,311 (151)

G-Protein-Coupled Receptor Kinase 2 Limits CCL21-Induced T Cell Migration via Phospholipase Cγ1 [PDF]

Receptors
Background/Objectives: G protein-coupled receptors (GPCRs) can promote ligand-biased signaling, yet the mechanisms that promote bias are not well understood.
Anahi Sanchez, Caitlin T. Winebrenner, Natalia Garcia, Brian Kaiser, Lyndsey Kilgore, Cesar I. Cardona, Daniel W. Bassuk, Mary E. Miller, Charles A. Bill, Laura A. Shannon, Brant M. Wagener, Amy Wagler, Manuel Llano, Colin A. Bill, Charlotte M. Vines   +14 more
doaj   +2 more sources

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction [PDF]

Cells
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes
Gizem Kayki Mutlu, Stephanie M. Kereliuk, Maya Hoteit, J. Kurt Chuprun, Umur Mendes, Yusuf Olgar, Walter J. Koch   +6 more
doaj   +2 more sources

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

Neurobiology of Disease, 2013
G protein-coupled receptor (GPCR) kinase 2 (GRK2) regulates cellular signaling via desensitization of GPCRs and by direct interaction with intracellular signaling molecules. We recently described that ischemic brain injury decreases cerebral GRK2 levels.
Cora H Nijboer, Hanneke Ldm Willemen, Pierre Gressens   +2 more
exaly   +3 more sources

Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction [PDF]

Cell Death Discovery
Hypoxia, a condition characterized by a temporary lack of oxygen, causes mitochondrial damage, which in turn leads to endothelial dysfunction. G-protein-coupled receptor kinase 2 (GRK2) plays a key role in vascular homeostasis and remodeling, influencing
Cristina Gatto, Maria Rosaria Rusciano, Daniela Sorriento, Paola Di Pietro, Angela Carmelita Abate, Valeria Visco, Nicola Montone, Pasquale Mone, Daniele Di Napoli, Pierpaolo Chivasso, Vito Domenico Bruno, Vincenza Valerio, Paolo Poggio, Guido Iaccarino, Gaetano Santulli, Carmine Vecchione, Albino Carrizzo, Michele Ciccarelli   +17 more
doaj   +2 more sources

GRK2 activates TRAF2–NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis [PDF]

Acta Pharmaceutica Sinica B
G protein-coupled receptor kinase 2 (GRK2) participates in the phosphorylation and desensitization of G protein-coupled receptor (GPCR), impacting various biological processes such as inflammation and cell proliferation.
Chenchen Han, Liping Jiang, Weikang Wang, Shujun Zuo, Jintao Gu, Luying Chen, Zhuo Chen, Jiajie Kuai, Xuezhi Yang, Liang Xu, Yang Ma, Wei Wei   +11 more
doaj   +2 more sources

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

EBioMedicine, 2016
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Laura Nogués, Clara Reglero, Veronica Rivas   +2 more
exaly   +3 more sources

Regulation of G protein-coupled receptor kinase 2 and its role in tumors [PDF]

Journal of Translational Medicine
Background G protein-coupled receptor kinase 2(GRK2) is a pivotal regulator of G protein-coupled receptor (GPCR) signal desensitization. It is increasingly recognized for its involvement in the pathogenesis of various malignancies through non-canonical ...
Chenmin Liu, Liuli Yang, Shiyu Peng, Jiangbo Jing, Lijuan Ma   +4 more
doaj   +2 more sources

GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity.
Yingjie Zhao, Wei Wei
exaly   +3 more sources

Unveiling the Role of GRK2: From Immune Regulation to Cancer Therapeutics [PDF]

Mediators of Inflammation
G protein-coupled receptors (GPCRs) represent humans’ most prominent family of membrane proteins. In contrast, G protein-coupled receptor kinases (GRKs) play a pivotal role in the rapid desensitization of GPCRs.
Xizhuang Gao, Dehuai Jing, Yaowen Zhang, Fengqin Zhu, Yonghong Yang, Guangxi Zhou   +5 more
doaj   +2 more sources

G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo [PDF]

Scientific Reports
Disease progression and drug resistance in patients with chronic lymphocytic leukaemia (CLL) depend on signals from the tumour microenvironment in lymphoid sites.
María Chiara Cassarino, Ana Colado, Valeria Sarapura Martinez, Claudio Martines, Alice Bonato, Martin Bertini, Miguel Pavlovksy, Rosario Custidiano, Fernando Raimundo Bezares, Pablo Elías Morande, Mónica Vermeulen, Romina Gamberale, Mirta Giordano, Dimitar G Efremov, Mercedes Borge   +14 more
doaj   +2 more sources