Results 1 to 10 of about 6,770 (152)

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases [PDF]

Frontiers in Pharmacology, 2019
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
Cristina Murga, Cristina Murga, Cristina Murga, Alba C. Arcones, Alba C. Arcones, Alba C. Arcones, Marta Cruces-Sande, Marta Cruces-Sande, Marta Cruces-Sande, Ana M. Briones, Ana M. Briones, Ana M. Briones, Mercedes Salaices, Mercedes Salaices, Mercedes Salaices, Federico Mayor Jr., Federico Mayor Jr., Federico Mayor Jr.   +17 more
doaj   +7 more sources

G Protein-Coupled Receptor Kinase 2 (GRK2) Regulates T Cell Response in a Murine Model of House Dust Mite-Induced Asthma [PDF]

Frontiers in Allergy, 2021
G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. It also regulates the functions and activity of other intracellular proteins in many cell types.
Ananth K. Kammala, Canchai Yang, Reynold A. Panettieri, Rupali Das, Hariharan Subramanian   +4 more
doaj   +2 more sources

Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases [PDF]

Nature Communications, 2016
High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate ...
Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J. Elliott, Christopher J. Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J. Koch   +10 more
doaj   +2 more sources

G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. [PDF]

Mol Biol Cell, 2013
G protein-coupled receptor kinases (GRKs) play a central role in regulating receptor signaling, but recent studies suggest a broader role in modulating normal cellular functions.
So CH, Michal A, Komolov KE, Luo J, Benovic JL.   +4 more
europepmc   +3 more sources

Regulation of G protein-coupled receptor kinase 2 and its role in tumors [PDF]

Journal of Translational Medicine
Background G protein-coupled receptor kinase 2(GRK2) is a pivotal regulator of G protein-coupled receptor (GPCR) signal desensitization. It is increasingly recognized for its involvement in the pathogenesis of various malignancies through non-canonical ...
Chenmin Liu, Liuli Yang, Shiyu Peng, Jiangbo Jing, Lijuan Ma   +4 more
doaj   +2 more sources

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis [PDF]

EBioMedicine, 2016
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor Jr., Petronila Penela   +14 more
doaj   +2 more sources

The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. [PDF]

Cell Adh Migr, 2012
G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative node in cell migration control. In addition to its canonical role in the desensitization of G protein-coupled receptors involved in chemotaxis, novel recently identified GRK2 ...
Lafarga V, Mayor F, Penela P.
europepmc   +3 more sources

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction [PDF]

Cells
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes
Gizem Kayki Mutlu, Stephanie M. Kereliuk, Maya Hoteit, J. Kurt Chuprun, Umur Mendes, Yusuf Olgar, Walter J. Koch   +6 more
doaj   +2 more sources

Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. [PDF]

PLoS ONE, 2013
Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction.
Qian Fan, Mai Chen, Lin Zuo, Xiying Shang, Maggie Z Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J Chuprun, Gerald W Dorn, Walter J Koch, Erhe Gao   +11 more
doaj   +2 more sources

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

Cell Reports
Summary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C.E. Welch   +11 more
doaj   +2 more sources