Results 1 to 10 of about 3,883 (111)

G Protein-Coupled Receptor Kinase 2 (GRK2) Regulates T Cell Response in a Murine Model of House Dust Mite-Induced Asthma [PDF]

Frontiers in Allergy, 2021
G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. It also regulates the functions and activity of other intracellular proteins in many cell types.
Ananth K. Kammala, Canchai Yang, Reynold A. Panettieri, Rupali Das, Hariharan Subramanian   +4 more
doaj   +2 more sources

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases [PDF]

Frontiers in Pharmacology, 2019
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
Cristina Murga, Cristina Murga, Cristina Murga, Alba C. Arcones, Alba C. Arcones, Alba C. Arcones, Marta Cruces-Sande, Marta Cruces-Sande, Marta Cruces-Sande, Ana M. Briones, Ana M. Briones, Ana M. Briones, Mercedes Salaices, Mercedes Salaices, Mercedes Salaices, Federico Mayor Jr., Federico Mayor Jr., Federico Mayor Jr.   +17 more
doaj   +2 more sources

Regulation of G protein-coupled receptor kinase 2 and its role in tumors [PDF]

Journal of Translational Medicine
Background G protein-coupled receptor kinase 2(GRK2) is a pivotal regulator of G protein-coupled receptor (GPCR) signal desensitization. It is increasingly recognized for its involvement in the pathogenesis of various malignancies through non-canonical ...
Chenmin Liu, Liuli Yang, Shiyu Peng, Jiangbo Jing, Lijuan Ma   +4 more
doaj   +2 more sources

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis [PDF]

EBioMedicine, 2016
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor Jr., Petronila Penela   +14 more
doaj   +2 more sources

Adenosine Receptor Functionality and Desensitization Machinery in a Neuronal Cell Model of Angelman Syndrome [PDF]

Journal of Developmental Biology
Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of maternal UBE3A expression, leading to disrupted proteostasis and synaptic dysfunction. Adenosine is a ubiquitous neuromodulator whose G protein-coupled receptors (ARs) regulate
Martina Contestabile, Jacqueline Fátima Martins de Almeida, Chiara De Cesari, Ilaria Tonazzini, Paolo Giovanni Artini, Simona Daniele   +5 more
doaj   +2 more sources

Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology [PDF]

Kinases and Phosphatases
Sustained neurohormonal stress, adverse myocardial remodeling, and inflammation are major components of heart failure (HF) progression. Alterations in circulating neurohormonal signaling are directly sensed by the β-adrenergic receptor (βAR), a system ...
Cody Reid Dotson, Lilly Underwood, Priscila Y. Sato   +2 more
doaj   +2 more sources

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction [PDF]

Cells
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes
Gizem Kayki Mutlu, Stephanie M. Kereliuk, Maya Hoteit, J. Kurt Chuprun, Umur Mendes, Yusuf Olgar, Walter J. Koch   +6 more
doaj   +2 more sources

Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. [PDF]

PLoS ONE, 2013
Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction.
Qian Fan, Mai Chen, Lin Zuo, Xiying Shang, Maggie Z Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J Chuprun, Gerald W Dorn, Walter J Koch, Erhe Gao   +11 more
doaj   +2 more sources

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

Cell Reports
Summary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C.E. Welch   +11 more
doaj   +2 more sources

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart

Cells, 2022
The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.
Joshua Abd Alla, Ursula Quitterer
doaj   +1 more source