Results 41 to 50 of about 6,839 (207)

The complex G protein‐coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets [PDF]

British Journal of Pharmacology, 2010
GRK2 is a ubiquitous member of the G protein‐coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRKs participate together with arrestins in the regulation of G protein‐coupled receptors (GPCR), a family of hundreds of membrane proteins of key physiological and pharmacological ...
Petronila, Penela, Cristina, Murga, Catalina, Ribas, Vanesa, Lafarga, Federico, Mayor   +4 more
openaire   +2 more sources

Agonist-induced internalization and desensitization of the apelin receptor [PDF]

, 2016
Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular ...
Lolait, Stephen J., McArdle, Craig A., O'Carroll, Anne-Marie, Pope, George R., Tilve, Sharada   +4 more
core   +2 more sources

G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.

PLoS ONE, 2015
Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj   +1 more source

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity

Cell Reports, 2016
Opioids remain the standard for analgesic care; however, adverse effects of systemic treatments contraindicate long-term administration. While most clinical opioids target mu opioid receptors (MOR), those that target the delta class (DOR) also ...
Allison Doyle Brackley, Ruben Gomez, Armen N. Akopian, Michael A. Henry, Nathaniel A. Jeske   +4 more
doaj   +1 more source

Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

Cellular Physiology and Biochemistry, 2018
G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional ...
Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei  Wei   +7 more
doaj   +1 more source

Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) is an essential regulator for many G protein‐coupled receptors and subsequent
Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Cai   +9 more
doaj   +1 more source

Role of G protein-coupled receptor kinases in cell migration [PDF]

, 2014
G protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the complex modulation of diverse aspects of cell motility.
Mayor, Federico, Nogués, Laura, Penela, Petronila   +2 more
core   +2 more sources

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Frontiers in Pharmacology, 2023
The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction.
Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Francisco Ciruela, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +11 more
doaj   +1 more source

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion

Redox Biology, 2019
In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion plays an active role in vasoocclusion.
Anson MacKinney, Emily Woska, Ivan Spasojevic, Ines Batinic-Haberle, Rahima Zennadi   +4 more
doaj   +1 more source