Results 61 to 70 of about 6,839 (207)

GRK et arrestines : la piste thérapeutique ? [PDF]

, 2006
La phosphorylation d’un récepteur couplé aux protéines G (RCPG) par une kinase spécifique, nommée GRK (G protein-coupled receptor kinase), est une première étape qui participe, avec l’action des arrestines, à l’arrêt de la transmission du signal, au ...
Kraimps, Jean-Louis, Métayé, Thierry, Perdrisot, Rémy   +2 more
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells

Frontiers in Pharmacology, 2019
G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified ...
Sailesh Palikhe, Wakana Ohashi, Takuya Sakamoto, Kohshi Hattori, Masaaki Kawakami, Tsugunobu Andoh, Hiromi Yamazaki, Yuichi Hattori, Yuichi Hattori   +8 more
doaj   +1 more source

Effects of exercise training on cardiovascular adrenergic system [PDF]

, 2013
In heart failure (HF), exercise has been shown to modulate cardiac sympathetic hyperactivation which is one of the earliest features of neurohormonal derangement in this syndrome and correlates with adverse outcome.
Allocca, Elena, BONADUCE, DOMENICO, FEMMINELLA, GRAZIA DANIELA, FORMISANO, ROBERTO, LEOSCO, DARIO, PARISI, VALENTINA, PETRAGLIA, LAURA   +6 more
core   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

β-adrenergic receptor responsiveness in aging heart and clinical implications [PDF]

, 2014
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the ...
Carlo eRengo, Carlo eRengo, Dario eLeosco, Domenico eBonaduce, Gennaro ePagano, Giuseppe eFurgi, Grazia Daniela eFemminella, Graziamaria eCorbi, Klara eKomici, Nicola eFerrara, Nicola eFerrara   +10 more
core   +2 more sources

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. [PDF]

PLoS Biology
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically ...
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers   +23 more
doaj   +1 more source

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. [PDF]

, 2003
G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation.
Barnhill, Jennifer F, Capel, W Darrell, Lefkowitz, Robert J, Lodowski, David T, Pitcher, Julie A, Tesmer, John JG   +5 more
core  

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 [PDF]

, 2013
Tumor vessel dysfunction is a pivotal event in cancer progression. Using an in vivo neovascularization model, we identified G protein–coupled receptor kinase 2 (GRK2) as a key angiogenesis regulator.
Belperio, Benjamin, Clara Reglero, David Hardisson, Dirkx, Federico Mayor, Gerald W. Dorn, Hellberg, Hellström, Laura Nogués, Marta Mendiola, María Miguel-Martín, Petronila Penela, Ramón García-Escudero, Ramón Muñoz-Chápuli, Rita Carmona, Song, Stenzel, Verónica Rivas, Yang   +19 more
core   +2 more sources